TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.40.5.1
Putative purine permease, YbbY.  The ybbY gene is in an operon involved with allantoin metabolism, and is flanked by allB, encoding allantoinase, and the glxK gene, encoding glycerate kinase II. Downstream of glxK is YlbA, encoding S-uridoglycine aminohydrolase, the second enzyme involved in allantoin degradation (Moraes and Reithmeier 2012).

Accession Number:P77328
Protein Name:Putative purine permease ybbY
Length:433
Molecular Weight:47239.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Purines

Cross database links:

Genevestigator: P77328
EchoBASE: EB3385
EcoGene: EG13620
eggNOG: COG2233
HEGENOM: HOG000117723
Entrez Gene ID: 945131   
Pfam: PF00860   
KEGG: eco:b0513   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0055085 P:transmembrane transport

References (4)

[1] “Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.”  Cusa E.et.al.   10601204
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MFNFAVSRES LLSGFQWFFF IFCNTVVVPP TLLSAFQLPQ SSLLTLTQYA FLATALACFA 
61:	QAFCGHRRAI MEGPGGLWWG TILTITLGEA SRGTPINDIA TSLAVGIALS GVLTMLIGFS 
121:	GLGHRLARLF TPSVMVLFML MLGAQLTTIF FKGMLGLPFG IADPNFKIQL PPFALSVAVM 
181:	CLVLAMIIFL PQRFARYGLL VGTITGWLLW YFCFPSSHSL SGELHWQWFP LGSGGALSPG 
241:	IILTAVITGL VNISNTYGAI RGTDVFYPQQ GAGNTRYRRS FVATGFMTLI TVPLAVIPFS 
301:	PFVSSIGLLT QTGDYTRRSF IYGSVICLLV ALVPALTRLF CSIPLPVSSA VMLVSYLPLL 
361:	FSALVFSQQI TFTARNIYRL ALPLFVGIFL MALPPVYLQD LPLTLRPLLS NGLLVGILLA 
421:	VLMDNLIPWE RIE