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2.A.40.6.5
Solute carrier family 23 member 1 (Na+/L-ascorbic acid transporter 1; Sodium-dependent vitamin C transporter 1) (hSVCT1; Yolk sac permease-like molecule 3) (Bürzle et al. 2013).

Accession Number:Q9UHI7
Protein Name:Solute carrier family 23 member 1
Length:598
Molecular Weight:64831.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+, L-ascorbic acid

Cross database links:

Genevestigator: Q9UHI7
eggNOG: COG2233
HEGENOM: HOG000038201
Entrez Gene ID: 9963   
Pfam: PF00860   
KEGG: hsa:9963   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0005737 C:cytoplasm
GO:0005887 C:integral to plasma membrane
GO:0043229 C:intracellular organelle
GO:0005624 C:membrane fraction
GO:0033300 F:dehydroascorbic acid transporter activity
GO:0008520 F:L-ascorbate:sodium symporter activity
GO:0015205 F:nucleobase transmembrane transporter activity
GO:0070890 F:sodium-dependent L-ascorbate transmembrane transporter activity
GO:0007420 P:brain development
GO:0019852 P:L-ascorbic acid metabolic process
GO:0006139 P:nucleobase-containing compound metabolic process
GO:0009636 P:response to toxin
GO:0070904 P:transepithelial L-ascorbic acid transport

References (8)

[1] “Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters.”  Faaland C.A.et.al.   9804989
[2] “Human Na(+)-dependent vitamin C transporter 1 (hSVCT1): primary structure, functional characteristics and evidence for a non-functional splice variant.”  Wang H.et.al.   10556483
[3] “Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2.”  Daruwala R.C.et.al.   10556521
[4] “Human vitamin C (L-ascorbic acid) transporter SVCT1.”  Wang Y.et.al.   10631088
[5] “Characterization of the genomic structure of the human vitamin C transporter SVCT1 (SLC23A2).”  Erichsen H.C.et.al.   11584081
[6] “Vitamin C transport systems of mammalian cells.”  Liang W.J.et.al.   11396616
[7] “The DNA sequence and comparative analysis of human chromosome 5.”  Schmutz J.et.al.   15372022
[8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRAQEDLEGR TQHETTRDPS TPLPTEPKFD MLYKIEDVPP WYLCILLGFQ HYLTCFSGTI 
61:	AVPFLLAEAL CVGHDQHMVS QLIGTIFTCV GITTLIQTTV GIRLPLFQAS AFAFLVPAKA 
121:	ILALERWKCP PEEEIYGNWS LPLNTSHIWH PRIREVQGAI MVSSVVEVVI GLLGLPGALL 
181:	NYIGPLTVTP TVSLIGLSVF QAAGDRAGSH WGISACSILL IILFSQYLRN LTFLLPVYRW 
241:	GKGLTLLRIQ IFKMFPIMLA IMTVWLLCYV LTLTDVLPTD PKAYGFQART DARGDIMAIA 
301:	PWIRIPYPCQ WGLPTVTAAA VLGMFSATLA GIIESIGDYY ACARLAGAPP PPVHAINRGI 
361:	FTEGICCIIA GLLGTGNGST SSSPNIGVLG ITKVGSRRVV QYGAAIMLVL GTIGKFTALF 
421:	SSLPDPILGG MFCTLFGMIT AVGLSNLQFV DMNSSRNLFV LGFSMFFGLT LPNYLESNPG 
481:	AINTGILEVD QILIVLLTTE MFVGGCLAFI LDNTVPGSPE ERGLIQWKAG AHANSDMSSS 
541:	LKSYDFPIGM GIVKRITFLK YIPICPVFKG FSSSSKDQIA IPEDTPENTE TASVCTKV