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2.A.40.7.2
Hypoxanthine/guanosine uptake transporter, PbuG (Johansen et al., 2003)

Accession Number:O34987
Protein Name:BACSU Hypoxanthine/guanine permease aka PbuG
Length:440
Molecular Weight:46191.00
Species:Bacillus subtilis [1423]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Hypoxanthine, Guanosine

Cross database links:

HEGENOM: HBG750189
RefSeq: NP_388518.1   
Entrez Gene ID: 936043   
Pfam: PF00860   
BioCyc: SUBTI:BSU06370-MONOMER   
KEGG: bsu:BSU06370   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0055085 P:transmembrane transport

References (5)

[1] “The 52 degrees-55 degrees segment of the Bacillus subtilis chromosome: a region devoted to purine uptake and metabolism, and containing the genes cotA, gabP and guaA and the pur gene cluster within a 34960 bp nucleotide sequence.”  Borriss R.et.al.   8969499
[2] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
[3] “Genetic and physiological characterization of Bacillus subtilis mutants resistant to purine analogs.”  Saxild H.H.et.al.   3110131
[4] “Definition of the Bacillus subtilis PurR operator using genetic and bioinformatic tools and expansion of the PurR regulon with glyA, guaC, pbuG, xpt-pbuX, yqhZ-folD, and pbuO.”  Saxild H.H.et.al.   11591660
[5] “Definition of a second Bacillus subtilis pur regulon comprising the pur and xpt-pbuX operons plus pbuG, nupG (yxjA), and pbuE (ydhL).”  Johansen L.E.et.al.   12923093

External Searches:

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  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKTFFQFDEL GTSYRNEIIG GLTTFLSMAY ILFVNPITLA LESVKDFPEA LRIDQGAVFT 
61:	ATALASAAGC ILMGLIARYP IAIAPGMGLN AFFAFSVVLG MGISWQAALS GVFISGLIFV 
121:	ALSLTGFREK IINAIPPELK LAVGAGIGLF ITFVGLQGSG IITANPSTLV TIGNIHSGPV 
181:	LLTIFGVIVT VILMVLRVNA GVFIGMLLTA VAGMIFGLVP VPTQIIGSVP SLAPTFGQAW 
241:	IHLPDIFSVQ MLIVILTFLF VGFFDTAGTL VAVATQAGLM KENKLPRAGR ALLADSSSIV 
301:	IGAVLGTSTT TSYVESSSGV AAGARSGFAA IVTGILFLLA TFFSPLLSVV TSNVTAPALI 
361:	IVGALMVAPL GKIAWDKFEV AVPAFLTMIM MPLTYSIATG IAIGFIFYPI TMVCKGKAKE 
421:	VHPIMYGLFV VFILYFIFLK