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2.A.40.7.4
  Adenine permease, YicO.  Also recognizes with low micromolar affinity N(6)-benzoyladenine, 2,6-diaminopurine, and purines (Papakostas et al. 2013).

Accession Number:P31440
Protein Name:Putative permease yicO
Length:444
Molecular Weight:46934.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Hypoxanthine, Guanosine

Cross database links:

Genevestigator: P31440
EchoBASE: EB1642
EcoGene: EG11691
eggNOG: COG2252
HEGENOM: HOG000244363
Entrez Gene ID: 948174   
Pfam: PF00860   
KEGG: eco:b3664   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0055085 P:transmembrane transport

References (4)

[1] “DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication.”  Burland V.D.et.al.   7686882
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MNNDNTDYVS NESGTLSRLF KLPQHGTTVR TELIAGMTTF LTMVYIVFVN PQILGAAQMD 
61:	PKVVFVTTCL IAGIGSIAMG IFANLPVALA PAMGLNAFFA FVVVGAMGIS WQTGMGAIFW 
121:	GAVGLFLLTL FRIRYWMISN IPLSLRIGIT SGIGLFIALM GLKNTGVIVA NKDTLVMIGD 
181:	LSSHGVLLGI LGFFIITVLS SRHFHAAVLV SIVVTSCCGL FFGDVHFSGV YSIPPDISGV 
241:	IGEVDLSGAL TLELAGIIFS FMLINLFDSS GTLIGVTDKA GLIDGNGKFP NMNKALYVDS 
301:	VSSVAGAFIG TSSVTAYIES TSGVAVGGRT GLTAVVVGVM FLLVMFFSPL VAIVPPYATA 
361:	GALIFVGVLM TSSLARVNWD DFTESVPAFI TTVMMPFTFS ITEGIALGFM SYCIMKVCTG 
421:	RWRDLNLCVV VVAALFALKI ILVD