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2.A.40.7.5
Purine base permease, GhxP or YjcD.  Transports purines such as guanine, hypoxanthine, and xanthine.  Also transports mutagenic modified purines such as 6-N-hydroxylaminopurine (HAP), 2-amino-HAP (AHAP), 6-mercaptopurine, 6-thioguanine, 1-methylguanine, 8-azaguanine, 6-thioguanine and 2-aminopurine (Kozmin et al. 2013; Papakostas et al. 2013).  

Accession Number:P0AF52
Protein Name:Putative permease yjcD
Length:449
Molecular Weight:45711.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Xanthine, guanine, Hypoxanthine

Cross database links:

Genevestigator: P0AF52
EchoBASE: EB1883
EcoGene: EG11939
eggNOG: COG2252
HEGENOM: HOG000244363
DIP: DIP-48113N
Entrez Gene ID: 948565   
Pfam: PF00860   
KEGG: eco:b4064   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005524 F:ATP binding
GO:0005215 F:transporter activity
GO:0055085 P:transmembrane transport

References (4)

[1] “Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes.”  Blattner F.R.et.al.   8265357
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSTPSARTGG SLDAWFKISQ RGSTVRQEVV AGLTTFLAMV YSVIVVPGML GKAGFPPAAV 
61:	FVATCLVAGL GSIVMGLWAN LPLAIGCAIS LTAFTAFSLV LGQHISVPVA LGAVFLMGVL 
121:	FTVISATGIR SWILRNLPHG VAHGTGIGIG LFLLLIAANG VGLVIKNPLD GLPVALGDFA 
181:	TFPVIMSLVG LAVIIGLEKL KVPGGILLTI IGISIVGLIF DPNVHFSGVF AMPSLSDENG 
241:	NSLIGSLDIM GALNPVVLPS VLALVMTAVF DATGTIRAVA GQANLLDKDG QIIDGGKALT 
301:	TDSMSSVFSG LVGAAPAAVY IESAAGTAAG GKTGLTAITV GVLFLLILFL SPLSYLVPGY 
361:	ATAPALMYVG LLMLSNVAKI DFADFVDAMA GLVTAVFIVL TCNIVTGIMI GFATLVIGRL 
421:	VSGEWRKLNI GTVVIAVALV TFYAGGWAI