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2.A.41.2.1
Purine-specific nucleoside:Na+ symporter

Accession Number:Q62773
Protein Name:CNT2 aka SPNT
Length:659
Molecular Weight:72615.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Purines, Na+

Cross database links:

Genevestigator: Q62773
eggNOG: roNOG09100
RefSeq: NP_113852.1   
Entrez Gene ID: 60423   
Pfam: PF07670    PF07662    PF01773   
KEGG: rno:60423   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0001882 F:nucleoside binding
GO:0005415 F:nucleoside:sodium symporter activity
GO:0006810 P:transport

References (3)

[1] “Primary structure and functional expression of a cDNA encoding the bile canalicular, purine-specific Na(+)-nucleoside cotransporter.”  Che M.et.al.   7775409
[2] “Transport of adenosine by recombinant purine- and pyrimidine-selective sodium/nucleoside cotransporters from rat jejunum expressed in Xenopus laevis oocytes.”  Yao S.Y.et.al.   8967974
[3] “A nucleoside transporter is functionally linked to ectonucleotidases in rat liver canalicular membrane.”  Che M.et.al.   1315767

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAKSEGRKSA SQDTSENGME NPGLELMEVG NLEQGKTLEE VTQGHSLKDG LGHSSLWRRI 
61:	LQPFTKARSF YQRHAGLFKK ILLGLLCLAY AAYLLAACIL NFRRALALFV ITCLVIFILA 
121:	CHFLKKFFAK KSIRCLKPLK NTRLRLWLKR VFMGAAVVGL ILWLALDTAQ RPEQLISFAG 
181:	ICMFILILFA CSKHHSAVSW RTVFWGLGLQ FVFGILVIRT EPGFNAFQWL GDQIQIFLAY 
241:	TVEGSSFVFG DTLVQSVFAF QSLPIIIFFG CVMSILYYLG LVQWVIQKIA WFLQITMGTT 
301:	AAETLAVAGN IFVGMTEAPL LIRPYLADMT LSEIHAVMTG GFATIAGTVL GAFISFGIDA 
361:	SSLISASVMA APCALALSKL VYPEVEESKF KSKEGVKLPR GEERNILEAA SNGATDAIAL 
421:	VANVAANLIA FLAVLAFINS TLSWLGEMVD IHGLTFQVIC SYVLRPMVFM MGVQWADCPL 
481:	VAEIVGVKFF INEFVAYQQL SQYKNKRLSG VEEWINGEKQ WISVKAEIIA TFSLCGFANL 
541:	TSIGITLGGL TSMVPQRKSD LCKLVVRALF TGACVSFISA CMAGILYVPR GAETDCVSFL 
601:	NTNFTNRTYE TYVCCRELFQ STLLNGTNMP SFSGPWQDKE SSLRNLAKCC DLYTSTVCA