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2.A.41.2.10
Nucleoside permease NupX

Accession Number:P33021
Protein Name:Nucleoside permease nupX
Length:416
Molecular Weight:43410.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Nucleosides

Cross database links:

Genevestigator: P33021
EchoBASE: EB1964
EcoGene: EG12029
eggNOG: COG1972
HEGENOM: HOG000267656
DIP: DIP-11922N
Entrez Gene ID: 946655   
Pfam: PF07670    PF07662    PF01773   
KEGG: eco:b2161   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0001882 F:nucleoside binding
GO:0005415 F:nucleoside:sodium symporter activity

References (4)

[1] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[2] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[3] “The RihA, RihB, and RihC ribonucleoside hydrolases of Escherichia coli. Substrate specificity, gene expression, and regulation.”  Petersen C.et.al.   11027694
[4] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDVMRSVLGM VVLLTIAFLL SVNKKKISLR TVGAALVLQV VIGGIMLWLP PGRWVAEKVA 
61:	FGVHKVMAYS DAGSAFIFGS LVGPKMDTLF DGAGFIFGFR VLPAIIFVTA LVSILYYIGV 
121:	MGILIRILGG IFQKALNISK IESFVAVTTI FLGQNEIPAI VKPFIDRLNR NELFTAICSG 
181:	MASIAGSTMI GYAALGVPVE YLLAASLMAI PGGILFARLL SPATESSQVS FNNLSFTETP 
241:	PKSIIEAAAT GAMTGLKIAA GVATVVMAFV AIIALINGII GGVGGWFGFE HASLESILGY 
301:	LLAPLAWVMG VDWSDANLAG SLIGQKLAIN EFVAYLNFSP YLQTAGTLDA KTVAIISFAL 
361:	CGFANFGSIG VVVGAFSAVA PHRAPEIAQL GLRALAAATL SNLMSATIAG FFIGLA