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2.A.41.2.2
Nonspecific nucleoside:Na+ symporter

Accession Number:Q62674
Protein Name:CNT1 aka SLC28A1
Length:648
Molecular Weight:71001.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Nucleosides, Na+

Cross database links:

Genevestigator: Q62674
eggNOG: roNOG08251
RefSeq: NP_446315.1   
Entrez Gene ID: 116642   
Pfam: PF07670    PF07662    PF01773   
KEGG: rno:116642   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0001882 F:nucleoside binding
GO:0005415 F:nucleoside:sodium symporter activity
GO:0005350 F:pyrimidine transmembrane transporter activity
GO:0015855 P:pyrimidine transport

References (1)

[1] “Cloning and functional expression of a complementary DNA encoding a mammalian nucleoside transport protein.”  Huang Q.-Q.et.al.   8027026

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MADNTQRQRE SISLTPMAHG LENMGAEFLE SMEEGRLPHS HSSLPEGEGG LNKAERKAFS 
61:	RWRSLQPTVQ ARSFCREHRQ LFGWICKGLL STACLGFLMV ACLLDLQRAL ALLIITCVVL 
121:	VFLAYDLLKR LLGSKLRRCV KFQGHSCLSL WLKRGLALAA GVGLILWLSL DTAQRPEQLV 
181:	SFAGICVFLV LLFAGSKHHR AVSWRAVSWG LGLQFVLGLF VIRTEPGFIA FQWLGDQIQV 
241:	FLSYTEAGSS FVFGEALVKD VFAFQVLPII IFFSCVMSVL YYLGLMQWVI LKIAWLMQVT 
301:	MGTSATETLS VAGNIFVSQT EAPLLIRPYL ADMTLSEVHV VMTGGYATIA GSLLGAYISF 
361:	GIDAASLIAA SVMAAPCALA LSKLVYPEVE ESKFRSENGV KLTYGDAQNL LEAASAGAAI 
421:	SVKVVANIAA NLIAFLAVLA FVNAALSWLG DMVDIQGLSF QLICSYVLRP VAFLMGVAWE 
481:	DCPVVAELLG IKFFLNEFVA YQELSQYKQR RLAGAEEWLG DKKQWISVRA EILTTYALCG 
541:	FANFSSIGIM LGGLTSLVPQ RRSDFSQIVL RALITGAFVS LLNACVAGIL YVPRGVEVDC 
601:	VSLLNQTVSS SSFEVYLCCR QVFQSTSSEF SQVALDNCCR FYNHTVCT