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2.A.41.2.4
Purine nucleoside, uridine, and 2'3'dideoxyinosine cladribrine:Na+ symporter, CNT2 (Na+/nucleoside = 1) (Owen et al., 2006)

Accession Number:O43868
Protein Name:CNT2 aka SLC28A2
Length:658
Molecular Weight:71926.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Purines, Uridine, 2'3'dideoxyinosine cladribrine, Na+

Cross database links:

Genevestigator: O43868 O43868
eggNOG: prNOG08627 COG1972
HEGENOM: HBG713614 HOG000267658
RefSeq: NP_004203.2   
Entrez Gene ID: 9153   
Pfam: PF07670    PF07662    PF01773   
OMIM: 606208  gene
KEGG: hsa:9153    hsa:9153   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0001882 F:nucleoside binding
GO:0005415 F:nucleoside:sodium symporter activity
GO:0015211 F:purine nucleoside transmembrane transporter...
GO:0006139 P:nucleobase, nucleoside, nucleotide and nucl...
GO:0015860 P:purine nucleoside transport
GO:0015211 F:purine nucleoside transmembrane transporter activity
GO:0006139 P:nucleobase-containing compound metabolic process

References (14)

[1] “Na+-dependent purine nucleoside transporter from human kidney: cloning and functional characterization.”  Wang J.et.al.   9435697
[2] “Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine.”  Ritzel M.W.L.et.al.   10087507
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2.”  Loewen S.K.et.al.   10455109
[6] “Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2.”  Owen R.P.et.al.   15861032
[7] “Identification and functional analysis of variants in the human concentrative nucleoside transporter 2, hCNT2 (SLC28A2) in Chinese, Malays and Indians.”  Li L.et.al.   17700367
[8] “Na+-dependent purine nucleoside transporter from human kidney: cloning and functional characterization.”  Wang J.et.al.   9435697
[9] “Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine.”  Ritzel M.W.L.et.al.   10087507
[10] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[11] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[12] “Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2.”  Loewen S.K.et.al.   10455109
[13] “Genetic analysis and functional characterization of polymorphisms in the human concentrative nucleoside transporter, CNT2.”  Owen R.P.et.al.   15861032
[14] “Identification and functional analysis of variants in the human concentrative nucleoside transporter 2, hCNT2 (SLC28A2) in Chinese, Malays and Indians.”  Li L.et.al.   17700367

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FASTA formatted sequence
1:	MEKASGRQSI ALSTVETGTV NPGLELMEKE VEPEGSKRTD AQGHSLGDGL GPSTYQRRSR 
61:	WPFSKARSFC KTHASLFKKI LLGLLCLAYA AYLLAACILN FQRALALFVI TCLVIFVLVH 
121:	SFLKKLLGKK LTRCLKPFEN SRLRLWTKWV FAGVSLVGLI LWLALDTAQR PEQLIPFAGI 
181:	CMFILILFAC SKHHSAVSWR TVFSGLGLQF VFGILVIRTD LGYTVFQWLG EQVQIFLNYT 
241:	VAGSSFVFGD TLVKDVFAFQ ALPIIIFFGC VVSILYYLGL VQWVVQKVAW FLQITMGTTA 
301:	TETLAVAGNI FVGMTEAPLL IRPYLGDMTL SEIHAVMTGG FATISGTVLG AFIAFGVDAS 
361:	SLISASVMAA PCALASSKLA YPEVEESKFK SEEGVKLPRG KERNVLEAAS NGAVDAIGLA 
421:	TNVAANLIAF LAVLAFINAA LSWLGELVDI QGLTFQVICS YLLRPMVFMM GVEWTDCPMV 
481:	AEMVGIKFFI NEFVAYQQLS QYKNKRLSGM EEWIEGEKQW ISVRAEIITT FSLCGFANLS 
541:	SIGITLGGLT SIVPHRKSDL SKVVVRALFT GACVSLISAC MAGILYVPRG AEADCVSFPN 
601:	TSFTNRTYET YMCCRGLFQS TSLNGTNPPS FSGPWEDKEF SAMALTNCCG FYNNTVCA