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2.A.41.2.5
Broadly selective nucleoside:Na+ cotransporter, hfCNT (transports uridine, thymidine, inosine, 3'-azido-3'deoxythymidine, 2'3'dideoxycytidine, and 2'3'dideoxyinosine) (Na+/uridine = 2)

Accession Number:Q9UA35
Protein Name:hfCNT
Length:683
Molecular Weight:75917.00
Species:Eptatretus stoutii (Pacific hagfish) [7765]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+, Uridine, Thymidine, Inosine, 3'-azido-3'deoxythymidine, 2'3'dideoxycytidine, 2'3'dideoxyinosine

Cross database links:

Pfam: PF07662    PF01773   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005415 F:nucleoside:sodium symporter activity
GO:0006810 P:transport

References (1)

[1] “Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2.”  Loewen S.K.et.al.   10455109

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSAFKARGVE NPSYEDPDEK QKPDLEMSKT NGIGVDNPSY YKNPEKYLGN ENEEGKSNND 
61:	NEEEEEGEED QGAVERCVNK FYGGIHNFYK RNKKIIHYTF LGLLLVGYFA LVIAACIVNF 
121:	KQSLALLVLT LIAIFFFFWD LFIAKYGDKI AEALKPCQKF LDNHWSIIRW FVYGALLLAV 
181:	ILWLTLDTAK RGANQVIPFF GLILYILLVF IFSKHPTKVR WRIVIWGLLL QFIFGLIILR 
241:	TKPGLDAFNW LGIQVQTFLK YTDAGSRFLF GDDFQDHFFA FAVLPIVIFF STVMSMMYYL 
301:	GLMQWLILKV GWLMQITMGT SPMESMVSAG NIFVGQTESP LLIRPYLADL TISEMHSVMS 
361:	SGFATIAGSV LGAYISLGIP AAHLLTASVM SAPAALAISK TFWPETKKSK NSTQTSIKLE 
421:	KGQENNLVEA ASQGASAAVP LVANIAANLI AFLAVLAFIN ATLSWLGSMF NYPQFSFEII 
481:	CSYVLMPFAF MMGVNYDDSF LVAELLGMKT FFNEFVAYQR LSEYIHNRES GGPLFVDGVR 
541:	QYMSVRSEAI ATYALCGFAN FGSLGIMIGG LSSLAPHRKS DIASCGIRAL IAGTIACFST 
601:	ACIAGVLYIP ELYCPNLLMS TLFENGTTVN TTNLMSCCTD LFKSTTMLTP KNITFTEGFN 
661:	TTMLNGCCTF FPSGFNCSEV RPE