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2.A.41.2.7
Broad specificity nucleoside:H+ symporter (1:1 stoichiometry). Adenosine, uridine, inosine, and guanosine are transported but not cytidine, thymidine or the nucleobase hypoxanthine (Km range: 15-65 μM). Purine and uridine nucleoside drug analogues including cordycepin (3'-deoxyadenosine) are substrates.

Accession Number:Q874I3
Protein Name:H+/nucleoside cotransporter aka CNT
Length:608
Molecular Weight:67722.00
Species:Candida albicans (Yeast) [5476]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Nucleosides, H+

Cross database links:

Pfam: PF07662    PF01773   

Gene Ontology

GO:0016020 C:membrane
GO:0005415 F:nucleoside:sodium symporter activity
GO:0006810 P:transport

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVSPSTDKAP SIVELTPETY QQDVSSDSID LESGTKKLQN ESALQSHEYT TNIDETSSSN 
61:	TASKLTYIQK LKIRFPYYRL AIDIFIGCFF TAWWLSIVIQ PKHRHQWLIP TVIWGMIMVR 
121:	LITWHIKILP WLLNKVKIVW DFFTGYVYKV LSKKYQRLIT GAVITVGVIL LGTFVPSETE 
181:	YSKRKDRAIS FFGCIVAIFL LFVTSKAPSK INWNAVIGGM LMQFIIALFV LRTKCGYDVF 
241:	NFISTLAREL LGFAKDGVAF LTNKDVSQLG MFFFTVLPSV AFFVAFIHIW YYFGVIQWAI 
301:	RKFAYFFFWT LRVSGAEAIT AAASPFIGIG ESAILIKDLM PYLTKAELHQ IMTSGFSTIS 
361:	GAVLVGYIGL GLNPQALVSS CVMSIPASLA VSKLRYPELE NPISSGTVMI PKVEDSEAAR 
421:	EKSKDEPQNV LQAFSNGATL GLRIAGTMMI QCMCIIGLVA LCNGILTWFG NYWNIDHLTL 
481:	ELILSYIFYP IGFLLGTPRN EILLVNKLIA YKFIQNEYVA YNLLTNEAPY NEMSKRGTLI 
541:	ATYACCGFAN LGSLGITLGV LNTLTNNSRA KDISSSIISA LFCGAIATML SAAIAGMVMH 
601:	DLNTFHIN