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2.A.42.2.4
Inner membrane inducible, anaerobic, cysteine uptake transport protein, CyuP (DlsT; YhaO) of 443 aas and 11 TMSs (Loddeke et al. 2017). It is in a bicistronic operon with CyuA, an iron-sulfur-containing cysteine desulfidase, and this operon is regulated by the CyuR protein and induced maximally under anaerobic conditions. L-cysteine, D-cysteine, and a few other sulfur-containing compounds can serve as inducers. This system has been characterized both in E. coli and in S. enterica (Loddeke et al. 2017).

Accession Number:P42628
Protein Name:Inner membrane transport protein YhaO
Length:443
Molecular Weight:48315.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

Genevestigator: P42628
EchoBASE: EB2609
EcoGene: EG12754
eggNOG: COG0814
HEGENOM: HOG000275613
Entrez Gene ID: 947628   
KEGG: eco:b3110   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0006810 P:transport

References (4)

[1] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[2] “Escherichia coli K-12: a cooperatively developed annotation snapshot -- 2005.”  Riley M.et.al.   16397293
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEIASNKGVI ADASTPAGRA GMSESEWREA IKFDSTDTGW VIMSIGMAIG AGIVFLPVQV 
61:	GLMGLWVFLL SSVIGYPAMY LFQRLFINTL AESPECKDYP SVISGYLGKN WGILLGALYF 
121:	VMLVIWMFVY STAITNDSAS YLHTFGVTEG LLSDSPFYGL VLICILVAIS SRGEKLLFKI 
181:	STGMVLTKLL VVAALGVSMV GMWHLYNVGS LPPLGLLVKN AIITLPFTLT SILFIQTLSP 
241:	MVISYRSREK SIEVARHKAL RAMNIAFGIL FVTVFFYAVS FTLAMGHDEA VKAYEQNISA 
301:	LAIAAQFISG DGAAWVKVVS VILNIFAVMT AFFGVYLGFR EATQGIVMNI LRRKMPAEKI 
361:	NENLVQRGIM IFAILLAWSA IVLNAPVLSF TSICSPIFGM VGCLIPAWLV YKVPALHKYK 
421:	GMSLYLIIVT GLLLCVSPFL AFS