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2.A.43.1.3
The ERD-1 suppressor, ERS1

Accession Number:P17261
Protein Name:ERS1 aka YCR075C aka YCR75C
Length:260
Molecular Weight:30116.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Endosome membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

Genevestigator: P17261
eggNOG: fuNOG09301
HEGENOM: HBG204061
DIP: DIP-8250N
RefSeq: NP_010000.1   
Entrez Gene ID: 850438   
KEGG: sce:YCR075C   

Gene Ontology

GO:0010008 C:endosome membrane
GO:0000324 C:fungal-type vacuole
GO:0016021 C:integral to membrane
GO:0005774 C:vacuolar membrane
GO:0015184 F:L-cystine transmembrane transporter activity
GO:0005515 F:protein binding
GO:0015811 P:L-cystine transport

References (3)

[1] “ERS1 a seven transmembrane domain protein from Saccharomyces cerevisiae.”  Hardwick K.et.al.   2186379
[2] “The complete DNA sequence of yeast chromosome III.”  Oliver S.G.et.al.   1574125
[3] “ERS1 encodes a functional homologue of the human lysosomal cystine transporter.”  Gao X.-D.et.al.   15885099

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MVSLDDILGI VYVTSWSISM YPPIITNWRH KSASAISMDF VMLNTAGYSY LVISIFLQLY 
61:	CWKMTGDESD LGRPKLTQFD FWYCLHGCLM NVVLLTQVVA GARIWRFPGK GHRKMNPWYL 
121:	RILLASLAIF SLLTVQFMYS NYWYDWHNSR TLAYCNNLFL LKISMSLIKY IPQVTHNSTR 
181:	KSMDCFPIQG VFLDVTGGIA SLLQLIWQLS NDQGFSLDTF VTNFGKVGLS MVTLIFNFIF 
241:	IMQWFVYRSR GHDLASEYPL