TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*2.A.43.1.1









Lysosomal cystine transporter, cystinosin. Uses a cystine:H+ symport mechanism. H+ binds to an aspartate residue in one of the two PQ-loops (Ruivo et al., 2012).

Eukaryota
Metazoa
Cystinosin of Homo sapiens
*2.A.43.1.2









Cystinosin homolog
Eukaryota
Metazoa
CG17119 of Drosophila melanogaster
*2.A.43.1.3









The ERD-1 suppressor, ERS1

Eukaryota
Fungi
ERS1 of Saccharomyces cerevisiae (P17261)
*2.A.43.1.4









Cystinosin homolog
Eukaryota
Viridiplantae
At5g40670 of Arabidopsis thaliana
*2.A.43.2.1









The lysosomal lysine-arginine transporter, LAAT1 or PQ-loop repeat containing protein 2 (PQLC2) (291aas; 7 TMSs). Also transports the mixed disulfide of cysteine-cysteamine, a lysine analogue, as well as canavanine, a toxic arginine analogue. Cysteamine is used in the treatment of cystinosis (Liu et al., 2012; Jézégou et al. 2012).

Eukaryota
Metazoa
PQLC2 of Homo sapiens (Q6ZP29)
*2.A.43.2.2









The lysosomal lysine-arginine transporter, LAAT1, PQ-loop superfamily member (qx42 gene product; 310aas; 7 TMSs) (Liu et al., 2012).

Eukaryota
Metazoa
LAAT1 of Caenorhabditis elegans (Q95XZ6)
*2.A.43.2.3









Vacuolar (lysosomal) cationic amino acid transporter (YOL092W) (308aas; 7 TMSs), LAAT1.  Involved in cationic amino acid homeostasis (Jézégou et al. 2012).

Eukaryota
Fungi
LAAT1 of Saccharomyces cerevisiae (Q12010)
*2.A.43.2.4









PQ-loop repeat protein (320aas; 7 TMSs)

Eukaryota
Entamoeba
PQLR protein Entamoeba histolyticus (C4LT11)
*2.A.43.2.5









PQ-loop repeat protein (288aas; 7 TMSs)

Eukaryota
Viridiplantae
 PQLR protein of Arabidopsis thaliana (O49437)
*2.A.43.2.6









7 TMS protein 1 (319aas; 7 TMSs)

Eukaryota
Hexamitidae
7 TMS protein of Giardia lamblia (E1F7I8)
*2.A.43.2.7









Probable vacuolar (lysosomal) cationic amino acid exporter, RTC2 (Ypq3; Ybr147). Involved in amino acid homeostasis. Up-regulated by addition of ammonia or amino acids to a nitrogen-depleted medium (Jézégou et al. 2012). Resistant to fluconazole. Increased resistance to caspofungin. Suppresses CDC13-1 temperature sensitivity.

Eukaryota
Fungi
RTC2 of Saccharomyces cerevisiae
*2.A.43.2.8









Vacuolar (lysosomal) putative cationic amino acid exporter, Ypq2 (Ydr352); involved with cationic amino acid homeostasis (Jézégou et al. 2012).

Eukaryota
Fungi
Ypq2 of Saccharomyces cerevisiae
*2.A.43.2.9









PQ loop protein of 384 aas and 7 (3 + 4) TMSs

Eukaryota
Viridiplantae
PQ-loop protein of Populus trichcarpa
*2.A.43.2.10









The probable vacuolar amino acid transporter YPQ1 of 381 aas and 6 TMSs.

Eukaryota
Viridiplantae
Ypq1 of Sesamum indicum
*2.A.43.2.11









The probable vacuolar amino acid transporter Ypq1 of 381 aas and 6 TMSs

Eukaryota
Viridiplantae
Ypq1 of Gossypium raimondii].
*2.A.43.2.12









Uncharacterized protein of 282 aas and 7 (3 + 4) TMSs.

Eukaryota
Viridiplantae
UP of Gossypium raimondii
*2.A.43.3.1









The Lec15/Lec35 suppressor, SL15
Eukaryota
Metazoa
SL15 of Cricetulus griseus
*2.A.43.3.2









PQ-loop-containing protein 3 (PQLC3)

Eukaryota
Metazoa
PQLC3 of Mus musculus (Q8C6U2)
*2.A.43.4.1









Uncharacterized protein C4C5.03
Eukaryota
Fungi
SPAC4C5.03 of Schizosaccharomyces pombe