TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*2.A.47.1.1









Anion transporter of unknown specificity
Archaea
Euryarchaeota
Anion transporter of Methanospirillum hungatei (Q2FMC1)
*2.A.47.1.2









Renal sodium:sulfate cotransporter (Ssc, NaSi-1 or Nas1) (also transports tungstate, molybdate, thiosulfate and selenate) (Beck and Markovich 2000; Lee et al 2006; Li and Pajor, 2003; Bergeron et al. 2013).

Eukaryota
Metazoa
Ssc of Rattus norvegicus
*2.A.47.1.3









The brush boarder intestinal and renal electrogenic, Na -dependent, low affinity (0.1-4.0mM), dicarboxylate (succinate, fumarate, malate, α-ketoglutarate, oxaloacetate, L- and D-glutamate, and citrate):H cotransporter, NaDC-1 or SDCT1.  Functions in acid regulation.  An acidic pH  stimullates citrate uptake; acid stimulation is mediated by endothelin-1 (ET-1) and its receptor (Liu et al. 2010).

Eukaryota
Metazoa
NaDC-1 or SDCT1 of Rattus norvegicus (O35055)
*2.A.47.1.4









The basolateral intestinal and renal electrogenic, Na+-dependent high affinity (2-50µM) dicarboxylate:(Na+)3 cotransporter (NaDC-3) (substrate range similar to that of NDC-1 except that tricarboxylates are transported with very low affinity). Na+:succinate = 3:1. Also transports N-acetyl-L-aspartate, an abundant amino acid in the nervous system (Yodoya et al., 2006).
Eukaryota
Metazoa
NaDC-3 of Rattus norvegicus
*2.A.47.1.5









Basolateral Na+: di- and tricarboxylate (succinate cis-aconitate, citrate, etc.) cotransporter, fNaDC-3
Eukaryota
Metazoa
fNaDC-3 of Pseudopleuronectes americanus (the winter flounder)
*2.A.47.1.6









The tonoplast dicarboxylate (malate) transporter, AtDCT (Kovermann et al., 2007).  The ortholog (70% identity) in tomatos increases the malate while decreasing the citrate concentrations, influencing flavor (Liu et al. 2017).

Eukaryota
Viridiplantae
AttDT of malate:Na+ symporter (and possibly malate:citrate antiporter) of Arabidopsis thaliana
*2.A.47.1.7









Low affinity dicarboxylate:Na+ symporter, NaDC1 (INDY1) (relative affinities: succinate > fumarate > α-ketoglutarate > malate > lactate > maleate) (Fei et al., 2003).

Eukaryota
Metazoa
NaDC1 of Caenorhabditis elegans
*2.A.47.1.8









High affinity dicarboxylate:Na+ symporter, NaDC2 (INDY2) (relative affinities: fumarate > malate > α-ketoglutarate > maleate > succinate > lactate) (Fei et al., 2003)
Eukaryota
Metazoa
NaDC2 of Caenorhabditis elegans
*2.A.47.1.9









Na+-coupled citrate transporter (NaCT) (Km=20 μM) (also may transport dicarboxylates and other tricarboxylates with lower affinity) (Inoue et al., 2002b; Bergeron et al. 2013). Na+:citrate = 3-4:1 (Bergeron et al. 2013). Na+:citrate = 3-4:1 (Wada et al., 2006). 

Eukaryota
Metazoa
SLC13A5 of Homo sapiens
*2.A.47.1.10









Cation-independent, electroneutral tri- and di-carboxylate transporter with a preference for tricarboxylates, Indy (I'm not dead yet) [When Indy is mutated flies live about twice as long as wild type] (Inoue et al., 2002)
Eukaryota
Metazoa
Indy of Drosophila melanogaster (Q9VVT2)
*2.A.47.1.11









The Na+ (or Li+):dicarboxylate (2:1) symporter, SdcS (catalyzes succinate:succinate antiport as well as electroneutral symport in reconstituted proteoliposomes (Hall and Pajor, 2007; Joshi and Pajor, 2009).  Transports succinate, malate and fumarate with similar affiinities (7 μM, 8 μM and 15 μM, respectively), but aspartate and α-ketoglutarate with very low affinities (Hall and Pajor 2005; Hall and Pajor 2007). 

Bacteria
Firmicutes
SdcS of Staphylococcus aureus (Q2FFH9)
*2.A.47.1.12









The aerobic dicarboxylate (succinate (Km, 30 μM), fumarate (Km, 79 μM), malate (Km, 360 μM)) transporter, DcsT or DccT.  Also transports oxaloacetate with low affinity (Ebbighausen et al. 1991; Teramoto et al., 2008; Youn et al. 2008Youn et al. 2008).

Bacteria
Actinobacteria
DcsT (DccT) of Corynebacterium glutamicum (A4QAL6)
*2.A.47.1.13









The Na+-coupled dicarboxylate (succinate; malate; fumarate) transporter, SdcL (transports aspartate, α-ketoglutarate and oxaloacetate with low affinity). Km for succinate, ~6 μM; Km for Na+, 0.9 mM; Na :substrate = 2:1 (Strickler et al., 2009).

Bacteria
Firmicutes
SdcL of Bacillus licheniformis (Q65NC0)
*2.A.47.1.14









solute carrier family 13 (sodium/sulfate symporters), member 4, NaS2.  Transports anions such as sulfate, thiosulfate and selenate (Bergeron et al. 2013).

Eukaryota
Metazoa
SLC13A4 of Homo sapiens
*2.A.47.1.15









Solute carrier family 13 member 3 (Na+/dicarboxylate cotransporter 3) (NaDC-3) (hNaDC3) (Sodium-dependent high-affinity dicarboxylate transporter 2) (Bergeron et al. 2013).

Eukaryota
Metazoa
S13A3 of Homo sapiens
*2.A.47.1.16









Solute carrier family 13 member 1 (Renal and intestinal sodium/sulfate cotransporter) (Na+/sulfate cotransporter) (hNaSi-1).  Also transports thiosulfate and selenium.  It is inhibited by many di- and tri-valent organic and inorganic anions (Markovich 2013).

Eukaryota
Metazoa
SLC13A1 of Homo sapiens
*2.A.47.1.17









Solute carrier family 13 member 2 (Na /di- and tricarboxylate cotransporter 1) (NaDC-1) (Renal sodium/dicarboxylate cotransporter).  Transports citrate and other Krebs cycle intermediates across the apical membrane of kidney proximal tubules and small intestinal cells (Pajor and Sun 2010; Bergeron et al. 2013). Transmembrane helices 7 and 11 in NaDC1 contains residues critical for function (Pajor and Sun 2010; Pajor et al., 2011). The mouse ortholog can transport succinate and adipate, but the rabbit transporter transports only succinate. Multiple amino acids from TMSs 8, 9 and 10 contribute to the transport of adipate, and A504 plays an important role (Oshiro and Pajor 2006).

Eukaryota
Metazoa
SLC13A2 of Homo sapiens
*2.A.47.1.18









Organic acid transporter, SdcF.  Transports succinate, malate, fumarate, tartrate and oxaloacetate (A. Pajor, personal communication)

Bacteria
Firmicutes
SdcF of Bacillus licheniformis
*2.A.47.1.19









Solute carrier family 13, Slc13a1; Sodium/sulfate symporter, member 1, NaS1 of 583 aas and 13 - 14 TMSs.  Na+-sulfate cotransport is inhibited by thiosulfate, selenate, molybdate and tungstate (Markovich et al. 2008).

Eukaryota
Metazoa
NaS1 of Danio ririo
*2.A.47.2.1









Inorganic phosphate transporter, Pho87. Also transports selenite (Lazard et al., 2010).

Eukaryota
Fungi
Pho87 of Saccharomyces cerevisiae
*2.A.47.2.2









Vacuolar low affinity phosphate transporter, Pho91 (Estrella et al., 2008). Also transports selenite (Lazard et al., 2010).

Eukaryota
Fungi
Pho91 of Saccharomyces cerevisiae (P27514)
*2.A.47.2.3









Low affinity phosphate transporters (881aas). Also transports selenite (Lazard et al., 2010).

 

Eukaryota
Fungi
Pho90 of Saccharomyces cerevisiae (P39535)
*2.A.47.2.4









Contractile vacuole phosphate:Na+ symporter of 727 aas and 12 TMSs, Pho91 (Pho90; Pho87).  Has an N-terminal SPX domain and a C-terminal anion permease domain. Plays an indirect role in pyrophosphate and oligophosphate synthesis (Jimenez and Docampo 2015).

Eukaryota
Kinetoplastida
Pho91 of Trypanosoma cruzi
*2.A.47.3.1









2-oxoglutarate:malate antiporter (SodiTl)
Eukaryota
Viridiplantae
SodiTl of Spinacia oleracea
*2.A.47.3.2









Citrate:succinate antiporter (Pos et al. 1998).  Binds and presumably regulates the heterodimeric citrate lyase, CitE/CitF which converts citrate to succinate and acetate (Quentmeier et al. 1987).  These proteins form a metabolon which together catalyze citrate fermentation under anaerobic conditions.

Bacteria
Proteobacteria
CitT of E. coli (P0AE74)
*2.A.47.3.3









L-tartrate:succinate antiporter, TtdT (YgjE). (also takes up meso and L-tartrate and succinate; does not transport D-tartrate) (Kim and Unden, 2007).  It is induced in the presence of L- or meso tartrate under anaerobic conditions in the presence of TtdR (Kim et al. 2009).

Bacteria
Proteobacteria
TtdT (YgjE) of E. coli (P39414)
*2.A.47.3.4









The pmf-dependent citrate uptake system, Cit1 (Urbany and Neuhaus, 2008)
Bacteria
Proteobacteria
Cit1 of Erwinia carotovora subsp. atroseptica (Q6D017)
*2.A.47.3.5









Putative anion (tri- or di-carboxylic acid) transporter of 477 aas, YbhI.

Bacteria
Proteobacteria
YbhI of E. coli
*2.A.47.4.1









Sulfur-deprivation response protein
Bacteria
Cyanobacteria
SdrP of Synechocystis
*2.A.47.4.2









Antimonite resistance protein (inducible by both arsenite and antimonite).

Archaea
Euryarchaeota
ArsB of Halobacterium spNRC-1 (AAG20642)
*2.A.47.4.3









The Na+/sulfate symporter, Slt1 (Pootakham et al., 2010).

Eukaryota
Viridiplantae
Slt1 of Chlamydomonas reinhardtii (A8IJF8)
*2.A.47.4.4









The Na+/sulfate symporter, Slt2 (Pootakham et al., 2010).

Eukaryota
Viridiplantae
Slt2 of Chlamydomonas reinhardtii (A8IHV5)
*2.A.47.4.5









Na+:SO4= symporter

Bacteria
Firmicutes
Na+:So4 symporter of Bacillus halodurans (Q9K7H7)
*2.A.47.4.6









The oxyanion (molybdate, sulfate, tungstate and vanidate) permease PerO (Gisin et al., 2010).

Bacteria
Proteobacteria
PerO of Rhodobacter capsulatus (D5AQ60)
*2.A.47.4.7









Uncharacterized protein of 426 aas.

Bacteria
Proteobacteria
UP of E. coli
*2.A.47.4.8









Putative uncharacterized permease of 610 aas, YfbS

Bacteria
Proteobacteria
YfbS of E. coli
*2.A.47.5.1









Hypothetical Na+ cotransporter, Orfl
Archaea
Euryarchaeota
Orfl of Methanococcus jannaschii
*2.A.47.5.2









Dicarboxylate (succinate, fumarate, malate) transporter, vcINDY.  The 3-d structure is known to 3.2 Å resolution with citrate and Na+ bound (Mancusso et al. 2012).  May also transport citrate and glutamate with low affinity.  Can use Na+ or Li+ as the cotransported cation.  MtrF (TC#2.A.68.1.2) and YdaH (TC# 2.A.68.1.4) have been shown to have similar 3-d folds as vcINDY (Vergara-Jaque et al. 2015), confirming the assignment of these two families to the same superfamily (Prakash et al. 2003).

Bacteria
Proteobacteria
INDY of Vibrio cholerae
*2.A.47.5.3









The Na+-dependent C4-dicarboxylate (fumarate, succinate) uptake transporter, SdcA of 425 aas and 15 TMSs (Rhie et al. 2014).

Bacteria
Proteobacteria
SdcA of Actinobacillus succinogene
*2.A.47.6.1









Putative cation transporter
Archaea
Euryarchaeota
The putative cation transporter of Methanosarcina mazei (gi 21227352)
*2.A.47.6.2









DUF1646 protein of 351 aas and 10 TMSs

Archaea
Crenarchaeota
DUF1646 protein of Pyrobaculum neutrophilum (Thermoproteus neutrophilus)
*2.A.47.6.3









DUF1646 protein of 359 aas and 10 TMSs

Bacteria
Firmicutes
DUF1646 protein of Caldicellulosiruptor obsidiansis