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2.A.47.1.10
Cation-independent, electroneutral tri- and di-carboxylate transporter with a preference for tricarboxylates, Indy (I'm not dead yet) [When Indy is mutated flies live about twice as long as wild type] (Inoue et al., 2002)

Accession Number:Q9VVT2
Protein Name:INDY transporter protein
Length:590
Molecular Weight:65585.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Basolateral cell membrane1 / Multi-pass membrane protein2
Substrate Dicarboxylates, Tricarboxylates

Cross database links:

eggNOG: inNOG04038
DIP: DIP-18443N
RefSeq: NP_001163465.1    NP_524150.1    NP_730363.2    NP_730364.1   
Entrez Gene ID: 40049   
Pfam: PF00939   
BioCyc: DMEL-XXX-02:DMEL-XXX-02-017263-MONOMER    DMEL-XXX-02:DMEL-XXX-02-017264-MONOMER    DMEL-XXX-02:DMEL-XXX-02-017265-MONOMER   
KEGG: dme:Dmel_CG3979   

Gene Ontology

GO:0016323 C:basolateral plasma membrane
GO:0005887 C:integral to plasma membrane
GO:0015137 F:citrate transmembrane transporter activity
GO:0005515 F:protein binding
GO:0050833 F:pyruvate transmembrane transporter activity
GO:0015141 F:succinate transmembrane transporter activity
GO:0015746 P:citrate transport
GO:0008340 P:determination of adult lifespan
GO:0006848 P:pyruvate transport
GO:0006814 P:sodium ion transport
GO:0015744 P:succinate transport
GO:0055085 P:transmembrane transport

References (7)

[1] “Functional identity of Drosophila melanogaster Indy as a cation-independent, electroneutral transporter for tricarboxylic acid-cycle intermediates.”  Inoue K.et.al.   12186628
[2] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[3] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[4] “A Drosophila full-length cDNA resource.”  Stapleton M.et.al.   12537569
[5] “Large number of replacement polymorphisms in rapidly evolving genes of Drosophila. Implications for genome-wide surveys of DNA polymorphism.”  Schmid K.J.et.al.   10581279
[6] “Extended life-span conferred by cotransporter gene mutations in Drosophila.”  Rogina B.et.al.   11118146
[7] “Functional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy.”  Knauf F.et.al.   12391301

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MATETTKMIY TPPPLDIKME IEIGEQPQPP VKCSNFFANH WKGLVVFLVP LLCLPVMLLN 
61:	EGAEFRCMYL LLVMAIFWVT EALPLYVTSM IPIVAFPIMG IMSSDQTCRL YFKDTLVMFM 
121:	GGIMVALAVE YCNLHKRLAL RVIQIVGCSP RRLHFGLIMV TMFLSMWISN AACTAMMCPI 
181:	IQAVLEELQA QGVCKINHEP QYQIVGGNKK NNEDEPPYPT KITLCYYLGI AYASSLGGCG 
241:	TIIGTATNLT FKGIYEARFK NSTEQMDFPT FMFYSVPSML VYTLLTFVFL QWHFMGLWRP 
301:	KSKEAQEVQR GREGADVAKK VIDQRYKDLG PMSIHEIQVM ILFIFMVVMY FTRKPGIFLG 
361:	WADLLNSKDI RNSMPTIFVV VMCFMLPANY AFLRYCTRRG GPVPTGPTPS LITWKFIQTK 
421:	VPWGLVFLLG GGFALAEGSK QSGMAKLIGN ALIGLKVLPN SVLLLVVILV AVFLTAFSSN 
481:	VAIANIIIPV LAEMSLAIEI HPLYLILPAG LACSMAFHLP VSTPPNALVA GYANIRTKDM 
541:	AIAGIGPTII TIITLFVFCQ TWGLVVYPNL NSFPEWAQIY AAAALGNKTH