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2.A.47.1.11
The Na+ (or Li+):dicarboxylate (2:1) symporter, SdcS (catalyzes succinate:succinate antiport as well as electroneutral symport in reconstituted proteoliposomes (Hall and Pajor, 2007; Joshi and Pajor, 2009).  Transports succinate, malate and fumarate with similar affiinities (7 μM, 8 μM and 15 μM, respectively), but aspartate and α-ketoglutarate with very low affinities (Hall and Pajor 2005; Hall and Pajor 2007). 

Accession Number:Q2FFH9
Protein Name:Sodium-dependent dicarboxylate transporter aka SdcS
Length:520
Molecular Weight:57198.00
Species:Staphylococcus aureus (strain USA300) [367830]
Number of TMSs:15
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Na+, Li+, Dicarboxylates, Succinate, malate, Fumarate

Cross database links:

eggNOG: COG0471
HEGENOM: HBG616159
RefSeq: YP_494549.1   
Entrez Gene ID: 3913308   
Pfam: PF00939   
KEGG: saa:SAUSA300_18   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015293 F:symporter activity
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (1)

[1] “Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus.”  Diep B.A.et.al.   16517273

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAYFNQHQSM ISKRYLTFFS KSKKKKPFSA GQLIGLILGP LLFLLTLLFF HPQDLPWKGV 
61:	YVLAITLWIA TWWITEAIPI AATSLLPIVL LPLGHILTPE QVSSEYGNDI IFLFLGGFIL 
121:	AIAMERWNLH TRVALTIINL IGASTSKILL GFMVATGFLS MFVSNTAAVM IMIPIGLAII 
181:	KEAHDLQEAN TNQTSIQKFE KSLVLAIGYA GTIGGLGTLI GTPPLIILKG QYMQHFGYEI 
241:	SFAKWMIVGI PTVIVLLGIT WLYLRYVAFR HDLKYLPGGQ TLIKQKLDEL GKMKYEEKVV 
301:	QTIFVLASLL WITREFLLKK WEVTSSVADG TIAIFISILL FIIPAKNTEK HRRIIDWEVA 
361:	KELPWGVLIL FGGGLALAKG ISESGLAKWL GEQLKSLNGV SPILIVIVIT IFVLFLTEVT 
421:	SNTATATMIL PILATLSVAV GVHPLLLMAP AAMAANCAYM LPVGTPPNAI IFGSGKISIK 
481:	QMASVGFWVN LISAIIIILV VYYVMPIVLG IDINQPLPLK