TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.47.1.14
solute carrier family 13 (sodium/sulfate symporters), member 4, NaS2.  Transports anions such as sulfate, thiosulfate and selenate (Bergeron et al. 2013).

Accession Number:Q9UKG4
Protein Name:Solute carrier family 13 member 4
Length:626
Molecular Weight:69358.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+, Sulfate, Thiosulfate, Selenate

Cross database links:

Genevestigator: Q9UKG4 Q9UKG4
eggNOG: COG0471 COG0471
HEGENOM: HOG000278432 HOG000278432
Entrez Gene ID: 26266   
Pfam: PF00939   
KEGG: hsa:26266    hsa:26266   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0015382 F:sodium:sulfate symporter activity

References (10)

[1] “Molecular cloning and functional analysis of SUT-1, a sulfate transporter from human high endothelial venules.”  Girard J.-P.et.al.   10535998
[2] “The DNA sequence of human chromosome 7.”  Hillier L.W.et.al.   12853948
[3] “Human chromosome 7: DNA sequence and biology.”  Scherer S.W.et.al.   12690205
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Functional characterization and genomic organization of the human Na(+)-sulfate cotransporter hNaS2 gene (SLC13A4).”  Markovich D.et.al.   15607730
[6] “Molecular cloning and functional analysis of SUT-1, a sulfate transporter from human high endothelial venules.”  Girard J.-P.et.al.   10535998
[7] “The DNA sequence of human chromosome 7.”  Hillier L.W.et.al.   12853948
[8] “Human chromosome 7: DNA sequence and biology.”  Scherer S.W.et.al.   12690205
[9] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[10] “Functional characterization and genomic organization of the human Na(+)-sulfate cotransporter hNaS2 gene (SLC13A4).”  Markovich D.et.al.   15607730

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MGLLQGLLRV RKLLLVVCVP LLLLPLPVLH PSSEASCAYV LIVTAVYWVS EAVPLGAAAL 
61:	VPAFLYPFFG VLRSNEVAAE YFKNTTLLLV GVICVAAAVE KWNLHKRIAL RMVLMAGAKP 
121:	GMLLLCFMCC TTLLSMWLSN TSTTAMVMPI VEAVLQELVS AEDEQLVAGN SNTEEAEPIS 
181:	LDVKNSQPSL ELIFVNEESN ADLTTLMHNE NLNGVPSITN PIKTANQHQG KKQHPSQEKP 
241:	QVLTPSPRKQ KLNRKYRSHH DQMICKCLSL SISYSATIGG LTTIIGTSTS LIFLEHFNNQ 
301:	YPAAEVVNFG TWFLFSFPIS LIMLVVSWFW MHWLFLGCNF KETCSLSKKK KTKREQLSEK 
361:	RIQEEYEKLG DISYPEMVTG FFFILMTVLW FTREPGFVPG WDSFFEKKGY RTDATVSVFL 
421:	GFLLFLIPAK KPCFGKKNDG ENQEHSLGTE PIITWKDFQK TMPWEIVILV GGGYALASGS 
481:	KSSGLSTWIG NQMLSLSSLP PWAVTLLACI LVSIVTEFVS NPATITIFLP ILCSLSETLH 
541:	INPLYTLIPV TMCISFAVML PVGNPPNAIV FSYGHCQIKD MVKAGLGVNV IGLVIVMVAI 
601:	NTWGVSLFHL DTYPAWARVS NITDQA