TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.47.1.17
Solute carrier family 13 member 2 (Na /di- and tricarboxylate cotransporter 1) (NaDC-1) (Renal sodium/dicarboxylate cotransporter).  Transports citrate and other Krebs cycle intermediates across the apical membrane of kidney proximal tubules and small intestinal cells (Pajor and Sun 2010; Bergeron et al. 2013). Transmembrane helices 7 and 11 in NaDC1 contains residues critical for function (Pajor and Sun 2010; Pajor et al., 2011). The mouse ortholog can transport succinate and adipate, but the rabbit transporter transports only succinate. Multiple amino acids in TMSs 8, 9 and 10 contribute to the transport of adipate, and A504 plays an important role while TMSs 3 and 4 function in substrate recognitioin (Oshiro and Pajor 2006; Oshiro et al. 2006).

Accession Number:Q13183
Protein Name:Solute carrier family 13 member 2
Length:592
Molecular Weight:64410.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Citrate, Na+, Dicarboxylates

Cross database links:

Genevestigator: Q13183
eggNOG: COG0471
HEGENOM: HOG000278432
Entrez Gene ID: 9058   
Pfam: PF00939   
Drugbank: Drugbank Link   
KEGG: hsa:9058   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0015361 F:low affinity sodium:dicarboxylate symporter activity

References (4)

[1] “Molecular cloning and functional expression of a sodium-dicarboxylate cotransporter from human kidney.”  Pajor A.M.et.al.   8967342
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Associations between renal sodium-citrate cotransporter (hNaDC-1) gene polymorphism and urinary citrate excretion in recurrent renal calcium stone formers and normal controls.”  Okamoto N.et.al.   17470169

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MATCWQALWA YRSYLIVFFV PILLLPLPIL VPSKEAYCAY AIILMALFWC TEALPLAVTA 
61:	LFPLILFPMM GIVDASEVAV EYLKDSNLLF FGGLLVAIAV EHWNLHKRIA LRVLLIVGVR 
121:	PAPLILGFML VTAFLSMWIS NTATSAMMVP IAHAVLDQLH SSQASSNVEE GSNNPTFELQ 
181:	EPSPQKEVTK LDNGQALPVT SASSEGRAHL SQKHLHLTQC MSLCVCYSAS IGGIATLTGT 
241:	APNLVLQGQI NSLFPQNGNV VNFASWFSFA FPTMVILLLL AWLWLQILFL GFNFRKNFGI 
301:	GEKMQEQQQA AYCVIQTEHR LLGPMTFAEK AISILFVILV LLWFTREPGF FLGWGNLAFP 
361:	NAKGESMVSD GTVAIFIGII MFIIPSKFPG LTQDPENPGK LKAPLGLLDW KTVNQKMPWN 
421:	IVLLLGGGYA LAKGSERSGL SEWLGNKLTP LQSVPAPAIA IILSLLVATF TECTSNVATT 
481:	TIFLPILASM AQAICLHPLY VMLPCTLATS LAFMLPVATP PNAIVFSFGD LKVLDMARAG 
541:	FLLNIIGVLI IALAINSWGI PLFSLHSFPS WAQSNTTAQC LPSLANTTTP SP