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2.A.47.1.2
Renal sodium:sulfate cotransporter (Ssc, NaSi-1 or Nas1) (also transports tungstate, molybdate, thiosulfate and selenate) (Beck and Markovich 2000; Lee et al 2006; Li and Pajor, 2003; Bergeron et al. 2013).

Accession Number:Q07782
Protein Name:NASU aka Ssc aka SLC13A1 aka NASI1 aka NAS1
Length:595
Molecular Weight:66059.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+

Cross database links:

Genevestigator: Q07782
eggNOG: roNOG11689
RefSeq: NP_113839.1   
Entrez Gene ID: 58980   
Pfam: PF00939   
KEGG: rno:58980   

Gene Ontology

GO:0005903 C:brush border
GO:0016021 C:integral to membrane
GO:0015382 F:sodium:sulfate symporter activity
GO:0006814 P:sodium ion transport
GO:0008272 P:sulfate transport
GO:0055085 P:transmembrane transport

References (2)

[1] “Expression cloning of rat renal Na+/SO4(2-) cotransport.”  Markovich D.et.al.   7690140
[2] “cDNA cloning of a rat small-intestinal Na+/SO4(2-) cotransporter.”  Norbis F.et.al.   7816544

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKLLNYAFVY RRFLLVVFTV LVLLPLPLII RSKEAECAYI LFVIATFWIT EALPLSITAL 
61:	LPGLMFPMFG IMSSTHVASA YFKDFHLLLI GVICLATSIE KWNLHKRIAL RMVMMVGVNP 
121:	AWLTLGFMSS TAFLSMWLSN TSTAAMVMPI VEAVAQQITS AEAEAEATQM TYFNESAAQG 
181:	LEVDETIIGQ ETNERKEKTK PALGSSNDKG KVSSKMETEK NTVTGAKYRS KKDHMMCKLM 
241:	CLCIAYSSTI GGLTTITGTS TNLIFSEHFN TRYPDCRCLN FGSWFLFSFP VAVILLLLSW 
301:	IWLQWLFLGF NFKEMFKCGK TKTLKEKACA EVIKQEYEKL GPMRYQEIVT LVIFIVMALL 
361:	WFSRDPGFVT GWSVLFSEYP GYVTDSTVAL VAGILFFLIP AKKLTKMTST GDIIAFDYSP 
421:	LITWKEFQSF MPWDIAILVG GGFALADGCQ VSGLSSWIGS KLSPLGSLPV WLIILISSLI 
481:	VTSLTEVASN PATITILFPI LSPLAEAIHV NPLHILLPST LCTSFAFLLP VANPPNAIVF 
541:	SYGHLKVIDM VKAGLGVNIL GVAVVMLGMF TWIEPMFNLH EYPSWAPDIV NQTMP