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2.A.47.1.3
The brush boarder intestinal and renal electrogenic, Na -dependent, low affinity (0.1-4.0mM), dicarboxylate (succinate, fumarate, malate, α-ketoglutarate, oxaloacetate, L- and D-glutamate, and citrate):H cotransporter, NaDC-1 or SDCT1.  Functions in acid regulation.  An acidic pH  stimullates citrate uptake; acid stimulation is mediated by endothelin-1 (ET-1) and its receptor (Liu et al. 2010).

Accession Number:O35055
Protein Name:SDCT1 aka NADC-1
Length:587
Molecular Weight:64143.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Na+

Cross database links:

Genevestigator: O35055
eggNOG: maNOG11117
RefSeq: NP_113934.1   
Entrez Gene ID: 65202   
Pfam: PF00939   
KEGG: rno:65202   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015293 F:symporter activity
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (4)

[1] “Expression cloning and characterization of a novel multispecific organic anion transporter.”  Sekine T.et.al.   9228014
[2] “Cloning, functional characterization, and localization of a rat renal Na+-dicarboxylate transporter.”  Sekine T.et.al.   9691021
[3] “Characterization of a rat Na+-dicarboxylate cotransporter.”  Chen X.Z.et.al.   9694847
[4] “Gene and alternative splicing annotation with AIR.”  Florea L.et.al.   15632090

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MATCWPALWA YRFYLIVLCL PIFLLPLPLI VQTKEAYCAY SIILMALLWC TEALPLAVTA 
61:	LFPIVLFPLM GIMDASEVCI EYFKDTNILF VGGLMVAIAV EHWNLHKRIA LQVLLIIGVR 
121:	PALLLLGFML VTAFLSMWIS NTATTAMMVP IGHAVLEQLQ GSKKDVEGGN NNPTFELQEE 
181:	CPQKEVTKLD NGQPVSAPSE PRTQKTQEHH RFSQGLSLCI CYSASIGGIA TLTGTTPNLV 
241:	LQGQVNSLFP QNGNVVNFAS WFGFAFPTMI ILLLLAWLWL QVLFLGVNFR KNFGFGEGEE 
301:	ERKQAAFQVI KTQYRLLGPM SFAEKTVTVL FVLLVVLWFT REPGFFPGWG DTVFANEKGQ 
361:	SMASDGTVAI FISLVMFIIP SKIPGLMQDP KKPGKLKAPP AILTWKTVND KMPWNIVILL 
421:	GGGFALAKGS EQSGLSEWLG DKLTPLQHIP PSATAVILCL LIAIFTECTS NVATTTLFLP 
481:	ILASMAQAIC LHPLYVMLPC TLAASLAFML PVATPPNAIV FSFGGLKVSD MARAGFLLNI 
541:	IGVLAITLSI NSWSIPIFKL DTFPSWAHSN TSQCLLNPSN STVPGGL