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2.A.47.1.4
The basolateral intestinal and renal electrogenic, Na+-dependent high affinity (2-50┬ÁM) dicarboxylate:(Na+)3 cotransporter (NaDC-3) (substrate range similar to that of NDC-1 except that tricarboxylates are transported with very low affinity). Na+:succinate = 3:1. Also transports N-acetyl-L-aspartate, an abundant amino acid in the nervous system (Yodoya et al., 2006).

Accession Number:Q9Z0Z5
Protein Name:NaDC-3 aka SLC13A3 aka SDCT2 aka NADC3
Length:600
Molecular Weight:66099.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+, Dicarboxylates

Cross database links:

Genevestigator: Q9Z0Z5
Pfam: PF00939   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005624 C:membrane fraction
GO:0015137 F:citrate transmembrane transporter activity
GO:0015183 F:L-aspartate transmembrane transporter activity
GO:0015141 F:succinate transmembrane transporter activity
GO:0015810 P:aspartate transport
GO:0015746 P:citrate transport
GO:0006814 P:sodium ion transport
GO:0015744 P:succinate transport
GO:0055085 P:transmembrane transport

References (2)

[1] “Primary structure and functional characteristics of a mammalian sodium-coupled high affinity dicarboxylate transporter.”  Kekuda R.et.al.   9920886
[2] “Molecular and functional analysis of SDCT2, a novel rat sodium-dependent dicarboxylate transporter.”  Chen X.et.al.   10207168

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAALAALAKK VWSARRLLVL LLVPLALLPI LFALPPKEGR CLYVILLMAV YWCTEALPLS 
61:	VTALLPIILF PFMGILPSSK VCPQYFLDTN FLFLSGLIMA SAIEERNLHR RIALKVLMLV 
121:	GVQPARLILG MMVTTSFLSM WLSNTASTAM MLPIASAILK SLFGQRDTRK DLPREGEDST 
181:	AAVRGNGLRT VPTEMQFLAS SEGGHAEDVE APLELPDDSK EEEHRRNIWK GFLISIPYSA 
241:	SIGGTATLTG TAPNLILLGQ LKSFFPQCDV VNFGSWFIFA FPLMLLFLLV GWLWISFLYG 
301:	GMSWRGWRKK NSKLQDVAED KAKAVIQEEF QNLGPIKFAE QAVFILFCLF AILLFSRDPK 
361:	FIPGWASLFA PGFVSDAVTG VAIVTILFFF PSQKPSLKWW FDFKAPNSET EPLLSWKKAQ 
421:	ETVPWNIILL LGGGFAMAKG CEESGLSAWI GGQLHPLEHV PPLLAVLLIT VVIAFFTEFA 
481:	SNTATIIIFL PVLAELAIRL HVHPLYLMIP GTVSCSYAFM LPVSTPPNSI AFSTGHLLVK 
541:	DMVRTGLLMN LMGVLLLSLA MNTWAQAIFQ LGTFPDWANT HAANVTALPP ALTNNTVQTL