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2.A.47.1.7
Low affinity dicarboxylate:Na+ symporter, NaDC1 (INDY1) (relative affinities: succinate > fumarate > α-ketoglutarate > malate > lactate > maleate) (Fei et al., 2003).

Accession Number:Q93655
Protein Name:Sodium-dependent low-affinity dicarboxylate transporter 1
Length:582
Molecular Weight:64186.00
Species: [6239]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Dicarboxylates, Na+

Cross database links:

eggNOG: meNOG07240
HEGENOM: HBG616159
RefSeq: NP_510473.2   
Entrez Gene ID: 181585   
Pfam: PF00939   
KEGG: cel:F31F6.6   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015293 F:symporter activity
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (2)

[1] “Structural and functional characteristics of two sodium-coupled dicarboxylate transporters (ceNaDC1 and ceNaDC2) from Caenorhabditis elegans and their relevance to life span.”  Fei Y.-J.et.al.   12480943
[2] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916

External Searches:

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  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MARKRGISSL LLIYKQSFVI WGALLIFSPL LMFVGDSHGL QAKCLYCVAV MGSYWVFEAL 
61:	PLAITAFIPM ILFPLFGIMR SEEVARAYLP DTCFLFMGGL MVALAVEKCE LHARVALFVL 
121:	KTVGSEPARV MAGFMGVTGF LSMWISNTAT TALMVPILQS VITELVSNHR MEDLVALCEA 
181:	HHNSSRKHSV GMRRLSLPNE NNEIKREEMD TAMSPREQKM AKGLMLSVCF SANIGGAATI 
241:	TGTASNLVLV GQLNELFPGA DTGVNFLSWL IFAFPMVFCC LIYCWCVLYL LYLRDAPKGS 
301:	IIVTRKLQQK YNELHAFSFA EMAVIFCFAL LLVLWILREP QVVPGWGEMF KDEFVSDATS 
361:	AMFIVILLFT LPEKLPSSRG SSEQRKASSG LLDWATVQDR FPWSVLFLLG GGFALAAGVK 
421:	ESGLSHDIGA IMRYLDVFNH NIIMLICIII SVTLTNVCSN TVIASIFIPI VAELARSLEI 
481:	DPLNFMLPVT ISASFAFLLP VATPPNAIVF SSGYLKVFDM FVSGLCVTLG CVVLSMLNML 
541:	LWAGFVFNLH LFPQWAANPS PPLDVQDWAV ENNITFVGTS KL