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2.A.47.1.8
High affinity dicarboxylate:Na+ symporter, NaDC2 (INDY2) (relative affinities: fumarate > malate > α-ketoglutarate > maleate > succinate > lactate) (Fei et al., 2003)

Accession Number:Q21339
Protein Name:Sodium-dependent high-affinity dicarboxylate transporter 3
Length:566
Molecular Weight:62326.00
Species: [6239]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Dicarboxylates, Na+, Fumarate, malate, Alpha-ketoglutarate, Maleate, Succinate, Lactate

Cross database links:

eggNOG: meNOG07240
HEGENOM: HBG616159
RefSeq: NP_001022673.1    NP_871713.1   
Entrez Gene ID: 176429   
Pfam: PF00939   
KEGG: cel:K08E5.2   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015293 F:symporter activity
GO:0008340 P:determination of adult lifespan
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (2)

[1] “Structural and functional characteristics of two sodium-coupled dicarboxylate transporters (ceNaDC1 and ceNaDC2) from Caenorhabditis elegans and their relevance to life span.”  Fei Y.-J.et.al.   12480943
[2] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSLSLHLSGW PENSESRQRM LESSSSTNFV QHFVSREISN KERLLSLFRR LRNGLVLVLT 
61:	PLFFGQMLNW EGPEWKCAYC VCIIAVYWMS EVMPLAVTAM LPVVLFPLVG VLDANTTAKE 
121:	YMNDTNFLFI GGLIMAAAVE KCDLHERVAL SVLRCVGSEP KWIMLGFMTV TALLSSFISN 
181:	TATTAMMVPI GQSVVQQLIS SFQHHPTNGE RGRLGCKKMA TGLVLSICFA ANIGGTGTAT 
241:	GTPSNLVMLG QLSALFPKVD GSLNYVTWIF FAYPLMLLCL FVAWMTLVSF FLRDAPEKDE 
301:	AVTEMLKTRY NELPRMTYAE KSVFVCFCIL LSLWVFRNPG VVPGFGVFFK KGAYTDATSA 
361:	MIVAFLLFVL PSERPDLATY IKKEDLKKRG CLMDWKTMQE TFPWSVVLLL GGGFALAAGV 
421:	KESGLSLLIG NSLSSIEHLP LWILQLLTML IAMVITNICS NTVTASIFVP IVATLAQRAG 
481:	HHPFTLMLPT TLASSFAFIF PVGTPPNAIV FGSGMVKVSD MAFVGGIISL ELLVLTVLYM 
541:	NSIAYLTLPL LEFPTWAIIA NSTMQQ