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2.A.47.3.3
L-tartrate:succinate antiporter, TtdT (YgjE). (also takes up meso and L-tartrate and succinate; does not transport D-tartrate) (Kim and Unden, 2007).  It is induced in the presence of L- or meso tartrate under anaerobic conditions in the presence of TtdR (Kim et al. 2009).

Accession Number:P39414
Protein Name:TTDT aka YgiE aka YGJE aka B3063
Length:487
Molecular Weight:52906.00
Species:Escherichia coli [83333]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate L-tartrate, Succinate

Cross database links:

Genevestigator: P39414
EchoBASE: EB2294
EcoGene: EG12393
eggNOG: COG0471
HEGENOM: HBG321139
RefSeq: AP_003613.1    NP_417535.1   
Entrez Gene ID: 947576   
Pfam: PF00939   
BioCyc: EcoCyc:YGJE-MONOMER    ECOL168927:B3063-MONOMER   
KEGG: ecj:JW3035    eco:b3063   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015297 F:antiporter activity
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (8)

[1] “Possible new genes as revealed by molecular analysis of a 5-kb Escherichia coli chromosomal region 5' to the rpsU-dnaG-rpoD macromolecular-synthesis operon.”  Nesin M.et.al.   3297921
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Intrinsic and extrinsic approaches for detecting genes in a bacterial genome.”  Borodovsky M.et.al.   7984428
[5] “The Escherichia coli citrate carrier CitT: a member of a novel eubacterial transporter family related to the 2-oxoglutarate/malate translocator from spinach chloroplasts.”  Pos K.M.et.al.   9696764
[6] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996
[7] “Functional identification of ygiP as a positive regulator of the ttdA-ttdB-ygjE operon.”  Oshima T.et.al.   16804186
[8] “The L-tartrate/succinate antiporter TtdT (YgjE) of L-tartrate fermentation in Escherichia coli.”  Kim O.B.et.al.   17172328

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKPSTEWWRY LAPLAVIAII ALLPVPAGLE NHTWLYFAVF TGVIVGLILE PVPGAVVAMV 
61:	GISIIAILSP WLLFSPEQLA QPGFKFTAKS LSWAVSGFSN SVIWLIFAAF MFGTGYEKTG 
121:	LGRRIALILV KKMGHRTLFL GYAVMFSELI LAPVTPSNSA RGAGIIYPII RNLPPLYQSQ 
181:	PNDSSSRSIG SYIMWMGIVA DCVTSAIFLT AMAPNLLLIG LMKSASHATL SWGDWFLGML 
241:	PLSILLVLLV PWLAYVLYPP VLKSGDQVPR WAETELQAMG PLCSREKRML GLMVGALVLW 
301:	IFGGDYIDAA MVGYSVVALM LLLRIISWDD IVSNKAAWNV FFWLASLITL ATGLNNTGFI 
361:	SWFGKLLAGS LSGYSPTMVM VALIVVFYLL RYFFASATAY TSALAPMMIA AALAMPEIPL 
421:	PVFCLMVGAA IGLGSILTPY ATGPSPIYYG SGYLPTADYW RLGAIFGLIF LVLLVITGLL 
481:	WMPVVLL