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2.A.47.5.2
Dicarboxylate (succinate, fumarate, malate) transporter, vcINDY.  The 3-d structure is known to 3.2 Å resolution with citrate and Na+ bound (Mancusso et al. 2012).  May also transport citrate and glutamate with low affinity.  Can use Na+ or Li+ as the cotransported cation.  MtrF (TC#2.A.68.1.2) and YdaH (TC# 2.A.68.1.4) have been shown to have similar 3-d folds as vcINDY (Vergara-Jaque et al. 2015), confirming the assignment of these two families to the same superfamily (Prakash et al. 2003).

Accession Number:Q9KNE0
Protein Name:Transporter, NadC family
Length:462
Molecular Weight:49569.00
Species:Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) [243277]
Number of TMSs:15
Substrate Succinate, Fumarate, malate, Citrate, Na+, glutamate, Li+

Cross database links:

Structure:
4F35     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNRNDSVPLP TNTREWFLHR NSLIVLADVA LFLALYHFLP FEHNVVLGIS MLAFIAVLWL 
61:	TEALHVTVTA ILVPVMAVFF GIFETQAALN NFANSIIFLF LGGFALAAAM HHQGLDKVIA 
121:	DKVLAMAQGK MSVAVFMLFG VTALLSMWIS NTATAAMMLP LVLGVLSKVD ADKQRSTYVF 
181:	VLLGVAYSAS IGGIATLVGS PPNAIAAAEV GLSFTDWMKF GLPTAMMMLP MAIAILYFLL 
241:	KPTLNGMFEL DRAPVNWDKG KVVTLGIFGL TVFLWIFSSP INAALGGFKS FDTLVALGAI 
301:	LMLSFARVVH WKEIQKTADW GVLLLFGGGL CLSNVLKQTG TSVFLANALS DMVSHMGIFV 
361:	VILVVATFVV FLTEFASNTA SAALLIPVFA TVAEAFGMSP VLLSVLIAVA ASCAFMLPVA 
421:	TPPNAIVFAS GHIKQSEMMR VGLYLNIACI GLLTAIAMLF WQ