TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*2.A.48.1.1









Folate/folate derivative transporter, RFC1. Although oligomeric, each monomer provides the channel (Hou et al., 2010). Downregulated in Chronic Kidney Disease (CKD) in heart, liver, and brain causing malabsorption (Bukhari et al., 2011).  5-Aminoimidazole-4-carboxamide riboside (AICAR), an agent with diverse pharmacological properties, augments transport of folates and antifolates by promoting substrate:substrate antiport (Visentin et al. 2012).  Its role in antifolate cancer chemotherapy has been reviewed (Matherly et al. 2014).

Eukaryota
Metazoa
SLC19A1 of Homo sapiens
*2.A.48.1.2









Thiamine uptake transporter-1, THTR-1, the thiamine-responsive megaloblastic anemia (TRMA) protein (Manimaran et al. 2016). Downregulated in Chronic Kidney Disease (CKD) in heart, liver, and brain causing malabsorption (Bukhari et al., 2011).

Eukaryota
Metazoa
SLC19A2 of Homo sapiens
*2.A.48.1.3









The folate transporter, FolT-1 of 453 aas, with a Km for folate of 1.2μM and a Ki for Sulfasalazine of 0.1 mM. Folt-1 also transports reduced folate and substituted folate derivatives.  The system is maximally expressed in the pharynx and intestine, and it is developmentallyl regulated. DIDS, a general anion inhibitor, also inhibits (Balamurugan et al., 2007).  FOLT-1 function affects both the soma and the germline. folt-1(ok1460) hermaphrodites suffer severely diminished lifespan and germline defects that result in sterility. Germline defects associated with folate deficiency appear widespread in animals, being found in humans, mice, fruit flies, and nematodes (Austin et al. 2010).

Eukaryota
Metazoa
FolT-1 of Caenorhabditis elegans (Q17766)
*2.A.48.1.4









Thiamine transporter-2, ThTr-2. Downregulated in Chronic Kidney Disease (CKD) in heart, liver, and brain causing malabsorption (Bukhari et al., 2011).  Activated by microtubules but not microfilaments  (Subramanian et al. 2013). Activated by direct interaction with the 4 TMS protein, TM4 of the L6 family, member 4, TM4SF4 (P48230) (Subramanian et al. 2014).

Eukaryota
Metazoa
SLC19A3, Thiamine transporter-2 of Homo sapiens
*2.A.48.1.5









Slime mold RFC homologue
Eukaryota
Dictyosteliida
RFC homologue of Dictyostelium discoideum (Q559K0)
*2.A.48.1.6









Giardia RFC homologue

Eukaryota
Hexamitidae
RFC homologue of Giardia lamblia (A8BIM9)