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2.A.48.1.3
The folate transporter, FolT-1 of 453 aas, with a Km for folate of 1.2μM and a Ki for Sulfasalazine of 0.1 mM. Folt-1 also transports reduced folate and substituted folate derivatives.  The system is maximally expressed in the pharynx and intestine, and it is developmentallyl regulated. DIDS, a general anion inhibitor, also inhibits (Balamurugan et al., 2007).  FOLT-1 function affects both the soma and the germline. folt-1(ok1460) hermaphrodites suffer severely diminished lifespan and germline defects that result in sterility. Germline defects associated with folate deficiency appear widespread in animals, being found in humans, mice, fruit flies, and nematodes (Austin et al. 2010).

Accession Number:Q17766
Protein Name:Folt-1
Length:410
Molecular Weight:46532.00
Species:Caenorhabditis elegans GN=folt-1 PE=1 SV=2 [6239]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate folate, Folate derivatives

Cross database links:

eggNOG: meNOG10775
HEGENOM: HBG385651
RefSeq: NP_505833.2   
Entrez Gene ID: 179544   
Pfam: PF01770   
KEGG: cel:C06H2.4   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005542 F:folic acid binding
GO:0008518 F:reduced folate carrier activity
GO:0006810 P:transport

References (2)

[1] “Cloning and functional characterization of a folate transporter from the nematode Caenorhabditis elegans.”  Balamurugan K.et.al.   17475669
[2] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSWRTTTAIL CLYGAVKEFR PATPFLTPFL ASPEKNITLD ELYSQVYPYW TYSYMLALIP 
61:	MFILTDILRY KPIVMIEAIG LVATWALLVF GKGVWQMQIM QVSFGVASAA EIAYYSYIYS 
121:	IVDRKHYKRA TSYIRAAALM GKLVAFGLGQ TLISTHTSDY LVLNQISLGA VCLVTIIAIF 
181:	LPRVKSEKAK VSMRAHEIVE QQTVESVESV QTPKAVKMSY TREYFKKISE ELQICSKNQE 
241:	LLKWSLWWAL ASCGVYQVQN YTQSLWKELQ NNPDDVANGV VEFVNTALGA FLSLFIHHLS 
301:	IDWTLRYVLR ANVAKELSSN NHGLIFGCNT FVAVCLQSLL TLVVVDSRFL HLDIRTQFVI 
361:	YSGYFALVAS IFAFFFMISL FSKSSNAHTA QTTYEATNEI QEETVFLDQN