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2.A.49.1.1
Voltage-gated Cl- channel, Gef1

Accession Number:P37020
Protein Name:Voltage-gated chloride channel aka Gef1
Length:779
Molecular Weight:87683.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Cl-

Cross database links:

Genevestigator: P37020
eggNOG: fuNOG04461
HEGENOM: HBG735070
DIP: DIP-3949N
RefSeq: NP_012574.1   
Entrez Gene ID: 853497   
Pfam: PF00571    PF00654   
KEGG: sce:YJR040W   

Gene Ontology

GO:0034707 C:chloride channel complex
GO:0005783 C:endoplasmic reticulum
GO:0005768 C:endosome
GO:0000324 C:fungal-type vacuole
GO:0005797 C:Golgi medial cisterna
GO:0005886 C:plasma membrane
GO:0005515 F:protein binding
GO:0005247 F:voltage-gated chloride channel activity
GO:0006878 P:cellular copper ion homeostasis
GO:0006879 P:cellular iron ion homeostasis
GO:0006821 P:chloride transport
GO:0055085 P:transmembrane transport

References (7)

[1] “The GEF1 gene of Saccharomyces cerevisiae encodes an integral membrane protein; mutations in which have effects on respiration and iron-limited growth.”  Greene J.R.et.al.   7505388
[2] “A voltage-gated chloride channel in the yeast Saccharomyces cerevisiae.”  Huang M.-E.et.al.   7932715
[3] “Analysis of a 42.5 kb DNA sequence of chromosome X reveals three tRNA genes and 14 new open reading frames including a gene most probably belonging to the family of ubiquitin-protein ligases.”  Huang M.-E.et.al.   7668047
[4] “Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.”  Galibert F.et.al.   8641269
[5] “The yeast Arr4p ATPase binds the chloride transporter Gef1p when copper is available in the cytosol.”  Metz J.et.al.   16260785
[6] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258
[7] “A multidimensional chromatography technology for in-depth phosphoproteome analysis.”  Albuquerque C.P.et.al.   18407956

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPTTYVPINQ PIRDGEDVID TNRFTNIPET QNFDQFVTID KIAEENRPLS VDSDREFLNS 
61:	KYRHYREVIW DRAKTFITLS STAIVIGCIA GFLQVFTETL VNWKTGHCQR NWLLNKSFCC 
121:	NGVVNEVTST SNLLLKRQEF ECEAQGLWIA WKGHVSPFII FMLLSVLFAL ISTLLVKYVA 
181:	PMATGSGISE IKVWVSGFEY NKEFLGLLTL VIKSVALPLA ISSGLSVGKE GPSVHYATCC 
241:	GYLLTKWLLR DTLTYSTQYE YLTAASGAGV AVAFGAPIGG VLFGLEEIAS ANRFNSSTLW 
301:	KSYYVALVAI TTLKYIDPFR NGRVILFNVT YDRDWKVQEI PIFIALGIFG GLYGKYISKW 
361:	NINFIHFRKM YLSSWPVQEV LFLATLTALI SYFNEFLKLD MTESMGILFH ECVKNDNTST 
421:	FSHRLCQLDE NTHAFEFLKI FTSLCFATVI RALLVVVSYG ARVPAGIFVP SMAVGATFGR 
481:	AVSLLVERFI SGPSVIIPGA YAFLGAAATL SGITNLTLTV VVIMFELTGA FMYIIPLMIV 
541:	VAITRIILST SGISGGIADQ MIMVNGFPYL EDEQDEEEEE TLEKYTAEQL MSSKLITINE 
601:	TIYLSELESL LYDSASEYSV HGFPITKDED KFEKEKRCIG YVLKRHLASK IMMQSVNSTK 
661:	AQTTLVYFNK SNEELGHREN CIGFKDIMNE SPISVKKAVP VTLLFRMFKE LGCKTIIVEE 
721:	SGILKGLVTA KDILRFKRIK YREVHGAKFT YNEALDRRCW SVIHFIIKRF TTNRNGNVI