TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.49.1.3
The voltage-gated chloride channel, CLC-A (Zhu and Williamson, 2003) (required for capsule and laccase expression)

Accession Number:Q874K8
Protein Name:CLC-A
Length:864
Molecular Weight:96076.00
Species:Cryptococcus neoformans var. grubii (Filobasidiella neoformans var. grubii) [178876]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Secreted1
Substrate Cl-

Cross database links:

Pfam: PF00571    PF00654   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005247 F:voltage-gated chloride channel activity
GO:0006821 P:chloride transport
GO:0055085 P:transmembrane transport

References (1)

[1] “A CLC-type chloride channel gene is required for laccase activity and virulence in Cryptococcus neoformans.”  Zhu X.et.al.   14622414

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MPRQQSEDEH RICGQAFRSP RSPQGNPLER NSKLEDEEEL DLIRRYEDFS TVDWIQDSLH 
61:	ERTFQNKAPR SRVIAQLDRS DGAIGYLWRL IRRTLEEGEA YVVISLVGVI IGVSAALISI 
121:	ITTWLSDIKL GHCTTGWWLS RKFCCLEVSD ELEACAEWKN WGGVEPFRWI AYVLFAAAFS 
181:	FSAAYLVKNF APYAAGSGIS EIKCILGGFI INGFLSVETF FIKGLTLPLA IASGLAVGKE 
241:	GPSVHVACSV GNVVAKWFNR YERSHLKMRE IVTASSAAGV AVAFGSPIGG VLFSIEEMNQ 
301:	TYSNRTMWRS FVCALVATFT LASMDPFRTG KLVIFNVSYD RDWHYFEIPA YVLIGIFGGL 
361:	YGAFVIKFNV QMAAFRRKHL SGHGIFEAVA LASITAIIGY LNGFLRIDMT EMLSVLFREC 
421:	EGGGDYNGLC QASSQWRMVN SLLLATIIRT VFIIVSYGCK VPAGIFVPSM AVGATFGRMI 
481:	GILVKAMYNS YPSAPWFAAC APDAPCITPG TYAFLGAAAA MGGITRLTVT VVVIMFELTG 
541:	ALTYILPTMI VLLVTKAVSD QFGGGGISDH MIKFNGYPFL EKEDKEDPTD HAFIEPIANV 
601:	MKKDLIILEA TGVPLNHVVD IVQHTNYQGF PVVKSHEDQT IVGFVRKNEL RIALEKTRRV 
661:	RNLSFNATCT FQCIRAIPED AHELLERPDI LIPNREGRMT ANTGTENRED DGGEISHVDF 
721:	GQYVDDIPLT VAPKMPLEIV MQLFRRMGPR VILVSDQGRL TGLVTVKDVL RHELSEAHHR 
781:	SRSTHTPITP SHPAYAQSNG WDTEWTVDDE RGHGLEIVLE EGLEWTRSKA TWAYGAALER 
841:	WRDIRGQDRR AATFDYELDE GIQG