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2.A.49.2.13
Clh-3; Clc-3, Clh3, Clc3 of 1001 aas and 11 TMSs.  Isoform a: Voltage-gated chloride channel (Rutledge et al. 2002; Denton et al. 2005). Insensitive to depolarizing voltages; requires low voltages for activation; insensitive to chloride levels but has a mild sensitivity to low pH. Channel gating properties are conferred by the cytoplasmic C-terminus (He et al. 2006). Plays a role in egg laying by modulating hermaphrodite-specific neuron excitability and the ovulatory contractions of gap-junction-coupled gonadal sheath cells (Branicky et al. 2014). When active, may prevent tubular formation of the excretory canals (Hisamoto et al. 2008). Activated during oocyte meiotic maturation and by membrane hyperpolarization and cell swelling (Denton et al. 2004). Inhibited by Zn2+ and to a lesser extent by Cd2+(Rutledge et al. 2001).  Isoform b: Voltage-gated chloride channel sensitive to depolarizing conditioning voltages; requires stronger voltages for activation and activation is slower, is inhibited by low concentrations of chloride and is activated by low pH. Channel gating properties are conferred by the cytoplasmic C-terminus (He et al. 2006).

Accession Number:Q9BMK9
Protein Name:Chloride channel protein clh-3
Length:1001
Molecular Weight:110787.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Cl-

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FASTA formatted sequence
1:	MGIGTKILSK IEKNKTSDGL TIPLTPTTQK QSSSWCSFES IKTFFRTVIR DWIFLALLGF 
61:	IMASLSFGMD YAILNLQNGQ MRLFDLVKEY HFTLAYLVWV GYVVGLILLS AVCAHYIAPQ 
121:	AIGSGIPEMK TILRGVILKE YLSVRTLLSK MIGLTLSLGS GLPMGKEGPF VHVASVVASQ 
181:	LTRLVHGSSG GIFENESRSG EMLAAGCAVG VACTFSAPIG GVLFSIEVTS VYFAVRNYWR 
241:	GFFAATCSAT LFRILRMFSV SAAVTVEAHY QTNFPPQNVF LPQELPIFAL IGLVCGLAGS 
301:	IFVYLHRRTV LFLRRNWLAK MIFQKYWLIY PIFIATFISS LSFPLGLGKF MGGEERFSHT 
361:	MKEFFVDCAW TAPPNDSYAC PMPTSNATSS DSFDIRHWKG DNYDYSPFVT LSSFQVVYFF 
421:	LAILASTLPV PSGIFMPVFV LGAAFGRLVG EGVFSLDPYG HISGDIQFFV RPGVYAVVGA 
481:	AAFCGAVTHT VSVAVIVFEL TGQLCHLLPV MIAVLIANAV ASYLQPSIYD SIIRIKNLPY 
541:	LPDIPHTTSL YHQMLIEQFM ISPLVYIAKD STVGDIKRAL ETKTRIRAFP LVENMESLAL 
601:	VGSVSRSQLQ RYVDSQIGTK ARFAEATRRI KQRLEDEESE RKRREESKSD DTEDSLETTG 
661:	AGERRASRFL IVPVAKNGPQ VAKNETLTGL SEENARKILT VEEKQALFDA ASLATPKREM 
721:	SGKTINPVHI ESHHTIGDIF RSITHLSFGR QNFPKKNNHN EFDLFGEERT EWEDMMLNQK 
781:	LDLSQLDIDS TPFQLSEYTS LFKAHSLFSL LGLNRAYVTK KGQLIGVVAL KELRLAIEYL 
841:	QSGKVPTPGM SIFNEPPTEQ SIYEKSARLE SGRATGDAQN AAFVTDNGED DAQNDYIQPP 
901:	LEVVRRGALT PNRMSELTRL ENVRTTPESP HFEVSSPSTS SSCVSIDFSP LDAANSENGS 
961:	VGGLVLNVPS LPTRARSANE LTRQNTHVQI NLPDDVHDEK F