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2.A.49.2.7
The ClC-A of the trophozoite plasma membrane (Cl->Br->I->F->NO3- ). Functions as an ion channel, not a Cl:H+ antiporter; regulates cell pH and volume (Salas-Casas et al., 2006)

Accession Number:Q70S43
Protein Name:Chloride channel type CLC aka clcA
Length:668
Molecular Weight:74520.00
Species:Entamoeba histolytica [5759]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Cl-, Br-, I-, F-, nitrate

Cross database links:

RefSeq: XP_651175.2   
Entrez Gene ID: 3405494   
Pfam: PF00654   
KEGG: ehi:EHI_142170   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005247 F:voltage-gated chloride channel activity
GO:0006821 P:chloride transport
GO:0055085 P:transmembrane transport

References (2)

[1] “Identification and functional characterization of EhClC-A, an Entamoeba histolytica ClC chloride channel located at plasma membrane.”  Salas-Casas A.et.al.   16430698
[2] “The genome of the protist parasite Entamoeba histolytica.”  Loftus B.J.et.al.   15729342

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	METTHPLSSS PFTQDNTFEL FEIDDLEDGN NDIDNVLVKI QTDPTQNSFL VHHENKYLKL 
61:	IKRICLFQVF GYKGTLIHVV AFYLFLLGVV SAVIGVSMDI TVEKLQDLRL WLCSLVENSF 
121:	YKVIIWVIYT IVLVTMAFLW TKFISPTANG SGVPEMKVTL LGNRIPNLLT FKTLIAKVIG 
181:	LVFVLGGGMW AGKEGPFIHI SSCIASQLTR LPIFRFLRNS NELFMQMLST ATSCGVSSNF 
241:	GTAIGGLLFS VEVTATYFSV RNYWFGTFSS VIAAFTFRAI FNTYSHSPSL YSGLLSIDYS 
301:	FPSLQIKDSL ISILLGVICG LFAVLFVMSV STIFKTRQYL RKYKLGRIPY LYLVIVALFT 
361:	GVVTAPWYGE LSPFGYPTYT TLSQMYTNSS VKPLFGKHYL FALFLLFIAR FTITAMSISM 
421:	PVPVGLFSTN IVVGSVLGRF IGECFSVWGI SNNLGPSGMA IIGGACFVGS ITQTFSAAVI 
481:	MIELIDDISI LVPMLIATVI TICFSRFFTV CVYDKIAIDK KLPYIPDIQY SSNQTAEMVM 
541:	DTNLVLISEY TNLVDLKEIV DQFQTLPDKI LPVVNDLEHS VLLGQVKLSV LRKLLDAQIP 
601:	EHVANKFLLD YSECPLHLLR HTPLSQIHML FIAAEIDSAF VTSNGRLIGE INKKCLTEAI 
661:	NKQMKILF