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2.A.49.2.8
ClC-4 (catalyzes 2 Cl-:H+ exchange, but NO3- uniport (Bergsdorf et al., 2009). SCN- uncouples Cl- from H+ transport so anions are transported with high unitary transport rates. Voltage then influences transport as is observed for the gating of ion channels (Orhan et al., 2011).

Accession Number:P51793
Protein Name:Chloride channel protein 4
Length:760
Molecular Weight:84917.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Early endosome membrane1 / Multi-pass membrane protein2
Substrate Cl-, H+

Cross database links:

Genevestigator: P51793
HEGENOM: HBG735070
RefSeq: NP_001821.2   
Entrez Gene ID: 1183   
Pfam: PF00571    PF00654   
OMIM: 302910  gene
KEGG: hsa:1183   

Gene Ontology

GO:0031901 C:early endosome membrane
GO:0016021 C:integral to membrane
GO:0031902 C:late endosome membrane
GO:0015297 F:antiporter activity
GO:0005524 F:ATP binding
GO:0005247 F:voltage-gated chloride channel activity
GO:0006821 P:chloride transport
GO:0055085 P:transmembrane transport

References (3)

[1] “A gene from the Xp22.3 region shares homology with voltage-gated chloride channels.”  van Slegtenhorst M.A.et.al.   8069296
[2] “Identification of an acid-activated Cl- channel from human skeletal muscles.”  Kawasaki M.et.al.   10564087
[3] “Determinants of anion-proton coupling in mammalian endosomal CLC proteins.”  Zdebik A.A.et.al.   18063579

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MVNAGAMSGS GNLMDFLDEP FPDVGTYEDF HTIDWLREKS RDTDRHRKIT SKSKESIWEF 
61:	IKSLLDAWSG WVVMLLIGLL AGTLAGVIDL AVDWMTDLKE GVCLSAFWYS HEQCCWTSNE 
121:	TTFEDRDKCP LWQKWSELLV NQSEGASAYI LNYLMYILWA LLFAFLAVSL VRVFAPYACG 
181:	SGIPEIKTIL SGFIIRGYLG KWTLLIKTVT LVLVVSSGLS LGKEGPLVHV ACCCGNFFSS 
241:	LFSKYSKNEG KRREVLSAAA AAGVSVAFGA PIGGVLFSLE EVSYYFPLKT LWRSFFAALV 
301:	AAFTLRSINP FGNSRLVLFY VEYHTPWYMA ELFPFILLGV FGGLWGTLFI RCNIAWCRRR 
361:	KTTRLGKYPV LEVIVVTAIT AIIAYPNPYT RQSTSELISE LFNDCGALES SQLCDYINDP 
421:	NMTRPVDDIP DRPAGVGVYT AMWQLALALI FKIVVTIFTF GMKIPSGLFI PSMAVGAIAG 
481:	RMVGIGVEQL AYHHHDWIIF RNWCRPGADC VTPGLYAMVG AAACLGGVTR MTVSLVVIMF 
541:	ELTGGLEYIV PLMAAAVTSK WVADAFGKEG IYEAHIHLNG YPFLDVKDEF THRTLATDVM 
601:	RPRRGEPPLS VLTQDSMTVE DVETLIKETD YNGFPVVVSR DSERLIGFAQ RRELILAIKN 
661:	ARQRQEGIVS NSIMYFTEEP PELPANSPHP LKLRRILNLS PFTVTDHTPM ETVVDIFRKL 
721:	GLRQCLVTRS GRLLGIITKK DVLRHMAQMA NQDPESIMFN