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2.A.49.3.1
NO3-:H+ (or less efficiently, Cl-:H+) antiporter, ClC-A or CLCa (De Angeli et al., 2006; Bergsdorf et al., 2009). Responsible for nitrate uptake into vacuoles (Zifarelli and Pusch, 2009b).  It is up-regulated under salt stress conditions (Yang et al. 2018) and may play a role in nitrate and Cd2+ resistance (Yang et al. 2018) and may play a role in nitrate and Cd2+ resistance (Liao et al. 2019).

Accession Number:Q96325
Protein Name:Voltage-gated chloride channel aka CLC-A
Length:773
Molecular Weight:85444.00
Species:Arabidopsis thaliana (Mouse-ear cress)   [3702]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Golgi apparatus membrane1 / Multi-pass membrane protein2
Substrate nitrate, H+, Cl-

Cross database links:

Genevestigator: Q96325
Pfam: PF00571    PF00654   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005247 F:voltage-gated chloride channel activity
GO:0006821 P:chloride transport
GO:0055085 P:transmembrane transport

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MDEDGNLQIS NSNYNGEEEG EDPENNTLNQ PLLKRHRTLS STPLALVGAK VSHIESLDYE 
61:	INENDLFKHD WRSRSKAQVF QYIFLKWTLA CLVGLFTGLI ATLINLAVEN IAGYKLLAVG 
121:	YYIAQDRFWT GLMVFTGANL GLTLVATVLV VYFAPTAAGP GIPEIKAYLN GIDTPNMFGF 
181:	TTMMVKIVGS IGAVAAGLDL GKEGPLVHIG SCIASLLGQG GPDNHRIKWR WLRYFNNDRD 
241:	RRDLITCGSA SGVCAAFRSP VGGVLFALEE VATWWRSALL WRTFFSTAVV VVVLRAFIEI 
301:	CNSGKCGLFG SGGLIMFDVS HVEVRYHAAD IIPVTLIGVF GGILGSLYNH LLHKVLRLYN 
361:	LINQKGKIHK VLLSLGVSLL HQLLFGLPFL ANEACDPTID EICPTNGRSG NFKQFNCPNG 
421:	YYNDLSTLLL TTNDDAVRKH FLFKHSYEFG MVSLWIFFGL YCILGLITFG IATPSGLFLP 
481:	IILMGSAYGR MLGTAMGSYT NIDQGLYAVL GAASLMAGSM RMTVSLCVIF LELTNNLLLL 
541:	PITMFVLLIA KTVGDSFNLS IYEIILHLKG LPFLEANPEP WMRNLTVGEL NDAKPPVVTL 
601:	NGVEKVANIV DVLRNTTHNA FPVLDGADQN TGTELHGLIL RAHLVKVLKK RWFLNEKRRT 
661:	EEWEVREKFT PVELAEREDN FDDVAITSSE MQLYVDLHPL TNTTPYTVVQ SMSVAKALVL 
721:	FRSVGLRHLL VVPKIQASGM SPVIGILTRQ DLRAYNILQA FPHLDKHKSG KAR