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2.A.5.1.1
High affinity zinc-regulated zinc uptake transporter, Zrt1 of 376 aas and 8 TMSs.  May be a transceptor with both transport and receptor (signal transduction) functions (Diallinas 2017; Schothorst et al. 2017). Activated at the transcriptional level by Yap1 and Ace1 (Gomes et al. 2005). Zrt1 may also transport, or influence the uptake of Cd2+ (Gomes et al. 2005).

Accession Number:P32804
Protein Name:Zrt1 aka YGL255W aka NRC376
Length:376
Molecular Weight:41582.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Zn2+, Cd2+

Cross database links:

Genevestigator: P32804
eggNOG: fuNOG05620
HEGENOM: HBG598807
RefSeq: NP_011259.1   
Entrez Gene ID: 852637   
Pfam: PF02535   
KEGG: sce:YGL255W   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0000006 F:high affinity zinc uptake transmembrane tra...
GO:0006830 P:high-affinity zinc ion transport

References (4)

[1] “Identification of a gene encoding a novel zinc finger protein in Saccharomyces cerevisiae.”  Breitwieser W.et.al.   8322518
[2] “Sequence of a 39,411 bp DNA fragment covering the left end of chromosome VII of Saccharomyces cerevisiae.”  Coissac E.et.al.   8972578
[3] “The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.”  Tettelin H.et.al.   9169869
[4] “The ZRT2 gene encodes the low affinity zinc transporter in Saccharomyces cerevisiae.”  Zhao H.et.al.   8798516

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSNVTTPWWK QWDPSEVTLA DKTPDDVWKT CVLQGVYFGG NEYNGNLGAR ISSVFVILFV 
61:	STFFTMFPLI STKVKRLRIP LYVYLFAKYF GSGVIVATAF IHLMDPAYGA IGGTTCVGQT 
121:	GNWGLYSWCP AIMLTSLTFT FLTDLFSSVW VERKYGLSHD HTHDEIKDTV VRNTAAVSSE 
181:	NDNENGTANG SHDTKNGVEY YEDSDATSMD VVQSFQAQFY AFLILEFGVI FHSVMIGLNL 
241:	GSVGDEFSSL YPVLVFHQSF EGLGIGARLS AIEFPRSKRW WPWALCVAYG LTTPICVAIG 
301:	LGVRTRYVSG SYTALVISGV LDAISAGILL YTGLVELLAR DFIFNPQRTK DLRELSFNVI 
361:	CTLFGAGIMA LIGKWA