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2.A.5.1.11
Ferrous iron (Fe2+) transporting ZIP family member, LIT1, required for intracellular growth and virulence (Huynh et al. 2006). Also transports other metal ions less efficiently.  Residues involved in targetting and activity have been identified including His108, 283 and 309 (Jacques et al. 2010).

Accession Number:Q4Q5V1
Protein Name:Lit1
Length:432
Molecular Weight:45865.00
Species:Leishmania major [5664]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Cell outer membrane1 / Multi-pass membrane protein2
Substrate Fe2+

Cross database links:

HEGENOM: HBG598807
RefSeq: XP_001685297.1   
Entrez Gene ID: 5654245   
Pfam: PF02535   
KEGG: lma:LmjF31.3060   

Gene Ontology

GO:0016020 C:membrane
GO:0046873 F:metal ion transmembrane transporter activity
GO:0030001 P:metal ion transport
GO:0055085 P:transmembrane transport

References (1)

[1] “The genome of the kinetoplastid parasite, Leishmania major.”  Ivens A.C.et.al.   16020728

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	METAKLSVEA STRYLMELGY HVSAPLNADG SSAASAGEAG DSLCKGFAGA YSLGLHVGAL 
61:	FLILFVSLLG TAIPILGKCI PSLMRYPYVF SVAKSAATGV LLSVSTIHLI FEGAEAFSED 
121:	CIPAVLKSYR PLYFLLALIA VLLMQALDMQ LADIAERWMK AKLKRETEAV KAESKCNDEC 
181:	CGLSPDVDVG VTTGPAQADG PLIDERKSTS SKSDVQTTVP AAALDDCKVP LVAVSPKHPE 
241:	HYHHCDEPSA HGHQHLSVAP LRDMGYLRYV ISAVCLEFGV TLHSVFVGLD VGLKKDSELK 
301:	PLLVALVFHQ LFEGMAVGSR LVDAKFSVTL DVVLALVFSL SAPAGMAASA IAVSVSPSAM 
361:	SGSVFATVVA VLDTLCGGIL LYLAFTLLLG DFVADVKHYC CDGQRHRMAK KIILFVSLWV 
421:	GMGLMALVGN WL