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2.A.5.1.6
The Zn2+/Cd2+ transporter, ZNT1 (Nishida et al., 2011).  The histidine-rich loop between TMSs3 and 4 binds Cu2+ > Zn2+ > Ni2+ (Potocki et al. 2014).

Accession Number:Q9M7J1
Protein Name:Zn and Cd transporter ZNT1
Length:378
Molecular Weight:39550.00
Species:Thlaspi caerulescens (Alpine penny-cress) [107243]
Number of TMSs:8
Substrate Zn2+, Cd2+, Ni2+

Cross database links:

Pfam: PF02535   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005385 F:zinc ion transmembrane transporter activity

References (1)

[1] “The molecular physiology of heavy metal transport in the Zn/Cd hyperaccumulator Thlaspi caerulescens.”  Pence N.S.et.al.   10781104

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MASSPTKILC DAGESDLCRD DAAAFLLKFV AIASILLAGA AGVAIPLIGK NRRFLQTEGN 
61:	LFVAAKAFAA GVILATGFVH MLAGGTEALT NPCLPDYPWS KFPFPGFFAM VAALITLLVD 
121:	FMGTQYYESK QQRNEVAGGG EAAVVEETSS VLPVVVERGN DSKAFGEEDG GGMHIVGIRA 
181:	HAAHHNHSHS NAHGTFDGHA HGQSHGHVHV HGSHDVENGA RHVVVSQILE LGIVSHSIII 
241:	GLSLGVSQSP CTIRPLIAAL SFHQFFEGFA LGGCISQAQF KNKSAIIMAC FFALTAPIGI 
301:	GIGTAVASSF NSHSPGALVT EGILDSLSAG ILTYMALVDL IAADFLSKRM SCNVRLQVVS 
361:	YVMLFLGAGL MSALAIWA