TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*2.A.5.1.1









High affinity zinc-regulated zinc uptake transporter, Zrt1 of 376 aas and 8 TMSs.  May be a transceptor with both transport and receptor (signal transduction) functions (Diallinas 2017; Schothorst et al. 2017). Activated at the transcriptional level by Yap1 and Ace1 (Gomes et al. 2005). Zrt1 may also transport, or influence the uptake of Cd2+ (Gomes et al. 2005).

Eukaryota
Fungi
Zrt1 of Saccharomyces cerevisiae
*2.A.5.1.2









Iron regulated Fit1-mediated plasma membrane high affinity Fe2+ uptake transporter, Irt1 (also takes up Co2+, Mn2+, Zn2+ and possibly Cd2+) (Korshunova et al., 1999; Schaaf et al., 2006; Halimaa et al. 2014).  Targetted to the plasma membrane by Sorting nexin1 (Snx1; Q9FG38) (Ivanov et al. 2014).

Eukaryota
Viridiplantae
Irt1 of Arabidopsis thaliana
*2.A.5.1.3









Zinc/iron uptake transporter, Zip1 (Grass et al., 2005; Grotz et al., 1998)
Eukaryota
Viridiplantae
Zip1 of Arabidopsis thaliana (O81123)
*2.A.5.1.4









Iron-regulated Fit1-mediated (coregulated with Irt1) vacuolar high-affinity Fe2+ efflux (from the vacuole into the cytoplasm) transporter, Irt2 (also transports Zn2+ (Schaaf et al., 2006)
Eukaryota
Viridiplantae
Irt2 of Arabidopsis thaliana (O81850)
*2.A.5.1.5









Zinc (Zn2+) uptake transporter, ZIP8 (Ueno et al. 2010)

Eukaryota
Viridiplantae
ZIP8 of Oryza sativa (A3BI11)
*2.A.5.1.6









The Zn2+/Cd2+ transporter, ZNT1 (Nishida et al., 2011).  The histidine-rich loop between TMSs3 and 4 binds Cu2+ > Zn2+ > Ni2+ (Potocki et al. 2014).

Eukaryota
Viridiplantae
ZNT1 of Thlaspi caerulescens (Q9M7J1)
*2.A.5.1.7









The Zn2+/Cd2+ transporter ZNT2 (Nishida et al., 2011)

Eukaryota
Viridiplantae
ZNT2 of Thlaspi caerulescens (Q92XE7)
*2.A.5.1.8









Zinc-regulated transporter 1 (High-affinity zinc transport (uptake) protein Zrt1) (Boch et al. 2008).

Eukaryota
Fungi
Zrt1 of Schizosaccharomyces pombe
*2.A.5.1.9









Protein ZntC

Eukaryota
Dictyosteliida
ZntC of Dictyostelium discoideum
*2.A.5.1.10









ZIP family porter of 392 aas

Eukaryota
Peronosporales
ZIP family member of Phytophthora infestans (strain T30-4) (Potato late blight fungus)
*2.A.5.1.11









Ferrous iron (Fe2+) transporting ZIP family member, LIT1, required for intracellular growth and virulence (Huynh et al. 2006). Also transports other metal ions less efficiently.  Residues involved in targetting and activity have been identified including His108, 283 and 309 (Jacques et al. 2010).

Eukaryota
Kinetoplastida
LIT1 of Leishmania major
*2.A.5.1.12









Root iron transporter IRT1 of 364 aas and 9 TMSs.  Has an uncleaved signal peptide that targets the protein to the endoplasmic reticulum for transport to the plasma membrane (Zhang et al. 2014).

Eukaryota
Viridiplantae
IRT1 of Malus xiaojinensis (apple)
*2.A.5.1.13









Ferrous iron (Fe2+) uptake transporter of 347 aas and 9 TMSs.  Transports iron and possibly Cd2+ in this hyperaccumulating plant. Induced by iron deficiency and cadmium excess (Plaza et al. 2007).

Eukaryota
Viridiplantae
IRT1 of Noccaea caerulescens (Alpine penny-cress) (Thlaspi caerulescens)
*2.A.5.1.14









Low affinity zinc-regulated zinc uptake transporter, Zrt2 of 422 aas and 7 TMSs. Active in zinc-replete cells and is time-, temperature- and concentration-dependent.  It prefers zinc over other metals as its substrate (Zhao and Eide 1996).

Eukaryota
Fungi
Zrt2 of Saccharomyces cerevisiae
*2.A.5.1.15









Zinc transporter, Zrt1 of 468 aas and 7 TMSs.  Receives Zn2+ from the secreted, extracellular zincophore protein, Pra1 for uptake of the metal.  The binding site in Pra1 is in the C-terminal region of this 299 aa protein (Łoboda and Rowińska-Żyrek 2017). Pra1 is a cell surface protein with a single N-terminal TMS involved in the host-parasite interaction during candidal infection. With MP65,  it represents a major component of the biofilm matrix. It sequesters zinc from host tissues and mediates leukocyte adhesion and migration (Citiulo et al. 2012).

Eukaryota
Fungi
Zrt1/Pra1 of Candida albicans and Candida dubliniensis (Yeast)
*2.A.5.2.1









Golgi Mn2+ homeostasis protein (probably pumps Mn2+ into cytoplasm), ATX2 (Eide, D.J, 1998)

Eukaryota
Fungi
ATX2 of Saccharomyces cerevisiae
*2.A.5.3.1









Growth arrest-inducible protein, ZIP2 of 309 aas.  Zinc dyshomeostasis leads to augmented production of proinflammatory cytokines, promoting chronic inflammation and increasing the susceptibility to age-related diseases. ZIP2 plays a role in the immune system, especially during zinc deficiency, while a polymorphism in the coding region of ZIP2 (Gln/Arg/Leu) is associated with severe carotid artery disease (Giacconi et al. 2015).

Eukaryota
Metazoa
SLC39A2 of Homo sapiens
*2.A.5.3.2









Zn2+ uptake transporter, Zip1 (abundantly expressed; involved in zinc homeostasis rather than acquisition of dietary Zn2+) (Gaither and Eide, 2000).  Mouse Zip1, 2 and 3 play important noncompensatory roles under conditions of zinc deficiency (Kambe et al. 2008).

Eukaryota
Metazoa
SLC39A1 of Homo sapiens
*2.A.5.3.3









Zn2+ uptake transporter, Zip3 (poorly expressed; involved in Zn2+ homeostasis) (Dufner-Beattie et al., 2003).
Eukaryota
Metazoa
SLC39A3 of Homo sapiens
*2.A.5.3.4









Zinc transporter 1 (ZRT/IRT-like protein 1) (OsZIP1)

Eukaryota
Viridiplantae
ZIP1 of Oryza sativa
*2.A.5.3.5









Zinc transporter ZIP1 (DrZIP1) (Solute carrier family 39 member 1) (Zrt- and Irt-like protein 1) (ZIP-1)
Eukaryota
Metazoa
Slc39a1 of Danio rerio
*2.A.5.3.6









Zip1 (ZIP42C.1) Zn2+ uptake transporter of 352 aas; Zn/Fe regulated (Lye et al. 2013; Dechen et al. 2015).

Eukaryota
Metazoa
Zip1 of Drosophila melanogaster (Fruit fly)
*2.A.5.3.7









ZIP family member of 437 aas

Eukaryota
Apicomplexa
ZIP protein of Cryptosporidium parvum
*2.A.5.3.8









Zip3 or Zip89B Zinc uptake porter of 495 aas.

Eukaryota
Metazoa
Zip3 of Drosophila melanogaster
*2.A.5.4.1









Zip4 Zn2+ uptake transporter (Acrodermatitis enteropathica zinc-deficiency disease protein) (Dufner-Beattie et al., 2003).  The large cytoplasmic loop is an intrinsically disordered zinc binding domain (Bafaro et al. 2015). A modeled ZIP4 dimer possibly resembles the twelve TMS monomeric PiPT of the MFS, as a likely structural homologue (Antala et al. 2015).

Eukaryota
Metazoa
SLC39A4 of Homo sapiens
*2.A.5.4.2









Zinc transporter, LIV1 (essential for the nuclear localization of the zinc-finger protein Snail, a master regulator of the epithelial-mesenchymal transition in zebrafish gastrulation) (Yamashita et al., 2004)

Eukaryota
Metazoa
LIV1 in Danio rerio (Q6L8F3)
*2.A.5.4.3









Zip7 Golgi Zn2+ uptake (into the cytoplasm) transporter (Ke4, Slc39a7) (Huang et al., 2005). This protein can substitute for Iar1, the indole acetic acid-alanine resistance protein, of A. thaliana (Lasswell et al., 2000)

Eukaryota
Metazoa
SLC39A7 of Homo sapiens
*2.A.5.4.4









Bidirectional endoplasmic reticular Zn2+ transporter, Yke4 (346 aas; Kumanovics et al., 2006)
Eukaryota
Fungi
Yke4 (YIL023c) of Saccharomyces cerevisiae (P40544)
*2.A.5.4.5









Zip14 Zn2+/Fe2+/Mn2+/Cd2+ uptake transporter (mobilized to the sinusoidal membrane of the hepatocyte during acute inflammation) (Jenkitkasemwong et al. 2012; Pinilla-Tenas et al., 2011); KM for Fe2+= 0.002 μM.  The prion gene family may have descended from an ancestral LZT gene (Ehsani et al. 2012).  The gene is upregulated by iron loading (Nam et al. 2013). LIV-1 ZIP ectodomain shedding in prion-infected mice resembles the cellular response to transition metal starvation (Ehsani et al. 2012).  Zip14 promotes cellular assimilation of iron from transferrin (Zhao et al. 2010) and also plays a role in maintaining manganese homeostasis (Xin et al. 2017).

.

Eukaryota
Metazoa
SLC39A14 of Homo sapiens
*2.A.5.4.6









Zinc transporter, Zip10 (plays an essential role in the migratory activity of highly metastatic breast cancer cells) (Kagara et al., 2007).  May be an evolutionary precursor of prion proteins in mammals (Schmitt-Ulms et al. 2009).

Eukaryota
Metazoa
SLC39A10 of Homo sapiens
*2.A.5.4.7









The indole acetic acid-alanine resistance protein 1, Iar1 (Lasswell et al., 2000)
Eukaryota
Viridiplantae
Iar1 of Arabidopsis thaliana (Q9M647)
*2.A.5.4.8









The divalent cation (M2+): bicarbonate (HCO3-) transporter (M2+:HCO3- = 1:2). Transports Cd2+ and Zn2+, and probably Cu2+, Pb2+, and Hg2+ (based on competitive inhibition studies (Liu et al., 2008))
Eukaryota
Metazoa
Zip8 of Mus musculus (Q91W10)
*2.A.5.4.9









Probable Zn2+ transporter, Zip13 (SLC39A13). Mice deficient in Zn transporter Slc39a13/Zip13 show changes in bone, teeth and connective tissue reminiscent of the clinical spectrum of human Ehlers-Danlos syndrome (EDS) (Fukada et al., 2008).

Eukaryota
Metazoa
Zip13 of Mus musculus (Q8BZH0)
*2.A.5.4.10









Zn2+ transporter, Zip5 (540aas; 1+3+3 TMSs; processed to a 3+3 TMS protein) (Basolateral membrane; carries out serosal to mucosal transport)

Eukaryota
Metazoa
SLC39A5 of Homo sapiens
*2.A.5.4.11









The Zn2+ and Cd2+ uptake porter, ZipB (nonsaturable; electrogenic) (Lin et al. 2010).

Bacteria
Proteobacteria
ZipB of Bordetella bronchispetica (Q2KXZ6)
*2.A.5.4.12









ZIP13 Zn influx porter, an 8TMS homodimer with N- and C-termini facing the lumen of the Golgi. Important for connective tissue development. Its loss causes the Spondylocheiro dysplastic form of Ehlers-Danlos syndrome (Bin et al., 2011).

Eukaryota
Metazoa
SLC39A13 of Homo sapiens
*2.A.5.4.13









Solute carrier family 39, SLC39 (zinc transporter), member 6, ZIP6.  May be an evoltionary precursor of mammalian prion proteins (Schmitt-Ulms et al. 2009).

Eukaryota
Metazoa
SLC39A6 of Homo sapiens
*2.A.5.4.14









solute carrier family 39 (zinc transporter), member 12
Eukaryota
Metazoa
SLC39A12 of Homo sapiens
*2.A.5.4.15









Zinc/iron/manganese/cadmium transporter ZIP8 (BCG-induced integral membrane protein in monocyte clone 103 protein) (LIV-1 subfamily of ZIP zinc transporter 6, LZT-Hs6; Solute carrier family 39 member 8; Zrt- and Irt-like protein 8) (Jenkitkasemwong et al. 2012).  Functions in Cd2+ uptake, cell toxicity and hypertension (Zhang et al. 2015).

Eukaryota
Metazoa
SLC39A8 of Homo sapiens
*2.A.5.4.16









Zinc transporter Foi (Protein fear-of-intimacy) (Protein kastchen)

Eukaryota
Metazoa
Foi of Drosophila melanogaster
*2.A.5.4.17









Zinc importer, ZupT of 291 aas and 6 TMSs (Herzberg et al. 2014).

Bacteria
Proteobacteria
ZupT of Cupriavidus metallidurans (Ralstonia metallidurans)
*2.A.5.5.1









Broad specificity heavy metal divalent cation uptake transporter, ZupT (Fe2+, Co2+, Mn2+, Cd2+ and Zn2+ are transported) (Grass et al., 2005). Point mutations change the specificity and kinetics of metal uptake (Taudte and Grass, 2010). Important for virulence in Salmonella (Karlinsey et al., 2010).

Bacteria
Proteobacteria
ZupT of E. coli (P0A8H3)
*2.A.5.5.2









Zinc transporter ZIP11 (Solute carrier family 39 member 11) (Zrt- and Irt-like protein 11) (ZIP-11)
Eukaryota
Metazoa
SLC39A11 of Homo sapiens
*2.A.5.5.3









Zinc-regulated transporter 3, Zrt3 (Vacuolar membrane zinc transporter)

Eukaryota
Fungi
Zrt3 of Saccharomyces cerevisiae
*2.A.5.5.4









Probable zinc transporter zip2
Eukaryota
Fungi
zip2 of Schizosaccharomyces pombe
*2.A.5.5.5









Zinc transporter ZupT
Bacteria
Chlamydiae/Verrucomicrobia group
ZupT of Akkermansia muciniphila
*2.A.5.5.6









ZIP11, Zinc permease of 251 aas and 8 TMSs (Hudek et al. 2013).  Transports zinc as well as cadmium, cobalt, copper, manganese and nickel.

Bacteria
Cyanobacteria
Zinc/Iron permease of Nostoc punctiforme
*2.A.5.5.7









Zip family protein of 651 aas, ZIL2

Eukaryota
Viridiplantae
ZIL2 of Chlamydomonas reinhardtii (Chlamydomonas smithii)
*2.A.5.5.8









Zip family homologue of 553 aas and 16 TMSs

Eukaryota
Viridiplantae
ZIP family homologue of Volvox carteri
*2.A.5.6.1









Zip family member, ZIP9 (SLC39A9) (307aas; 8 TMSs).  The orthologue, Zip9, in the atlantic croaker (Micropogonias undulatus) is an androgen receptor that mediates testosterone-induced apoptosis of female ovarian follicle cells (Berg et al. 2014).

Eukaryota
Metazoa
SLC39A9 of Homo sapiens