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2.A.5.2.1
Golgi Mn2+ homeostasis protein (probably pumps Mn2+ into cytoplasm), ATX2 (Eide, D.J, 1998)

Accession Number:Q12067
Protein Name:Metal homeostasis factor ATX2
Length:313
Molecular Weight:34408.00
Species: [4932]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Golgi apparatus membrane1 / Multi-pass membrane protein2
Substrate Mn2+

Cross database links:

Genevestigator: Q12067
eggNOG: fuNOG09480
HEGENOM: HBG202834
DIP: DIP-3832N
RefSeq: NP_014722.1   
Entrez Gene ID: 854246   
Pfam: PF02535   
KEGG: sce:YOR079C   

Gene Ontology

GO:0000139 C:Golgi membrane
GO:0016021 C:integral to membrane
GO:0005384 F:manganese ion transmembrane transporter act...
GO:0030026 P:cellular manganese ion homeostasis
GO:0030001 P:metal ion transport
GO:0055085 P:transmembrane transport

References (5)

[1] “Suppression of oxidative damage by Saccharomyces cerevisiae ATX2, which encodes a manganese-trafficking protein that localizes to Golgi-like vesicles.”  Lin S.-J.et.al.   8887660
[2] “The sequence of a 54.7 kb fragment of yeast chromosome XV reveals the presence of two tRNAs and 24 new open reading frames.”  Valens M.et.al.   9133743
[3] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.”  Dujon B.et.al.   9169874
[4] “Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.”  Hu Y.et.al.   17322287
[5] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKFLGVILLA SFLLIATFLI GLIPLYYIDK QKSSIVTNQE GADSISDFTT NADTQTINDD 
61:	VSSYRVKIAV LSQFGIGMLL GTSFMLVIPE GIKACVEHDG NVGVNLLIGF LGVYVLDRLV 
121:	TLWVSRKQTV YTHDAVKFQS WKDIINHPRQ IWMNLIQNNV VFALFIHGLS DGIALGTTTN 
181:	NDSLLIVVLI AIVIHKIPAV LSLTSLMVSR QNLMKWEVIC NVFLFASSTP IGYIVLSLLN 
241:	LSHSPTMDWI SGNLLLMSGG SLLYASFTAF VGGDSHDHDL SVEQEVVLPH DESVYVLIGV 
301:	CIPLVISYCI SEE