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2.A.5.3.1
Growth arrest-inducible protein, ZIP2 of 309 aas.  Zinc dyshomeostasis leads to augmented production of proinflammatory cytokines, promoting chronic inflammation and increasing the susceptibility to age-related diseases. ZIP2 plays a role in the immune system, especially during zinc deficiency, while a polymorphism in the coding region of ZIP2 (Gln/Arg/Leu) is associated with severe carotid artery disease (Giacconi et al. 2015).

Accession Number:Q9NP94
Protein Name:Zinc transporter ZIP2
Length:309
Molecular Weight:32742.00
Species: [9606]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Zn2+

Cross database links:

Genevestigator: Q9NP94 Q9NP94 Q9NP94
eggNOG: prNOG18539 NOG321162 NOG321162
HEGENOM: HBG403167 HOG000236331 HOG000236331
Entrez Gene ID: 29986   
Pfam: PF02535   
KEGG: hsa:29986    hsa:29986    hsa:29986   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005385 F:zinc ion transmembrane transporter activity
GO:0055085 P:transmembrane transport
GO:0006829 P:zinc ion transport
GO:0016023 C:cytoplasmic membrane-bounded vesicle

References (15)

[1] “Subtraction cloning of growth arrest inducible genes in normal human epithelial cells.”  Yamaguchi S.et.al.   7751801
[2] “Functional expression of the human hZIP2 zinc transporter.”  Gaither L.A.et.al.   10681536
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The DNA sequence and analysis of human chromosome 14.”  Heilig R.et.al.   12508121
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Subtraction cloning of growth arrest inducible genes in normal human epithelial cells.”  Yamaguchi S.et.al.   7751801
[7] “Functional expression of the human hZIP2 zinc transporter.”  Gaither L.A.et.al.   10681536
[8] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[9] “The DNA sequence and analysis of human chromosome 14.”  Heilig R.et.al.   12508121
[10] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[11] “Subtraction cloning of growth arrest inducible genes in normal human epithelial cells.”  Yamaguchi S.et.al.   7751801
[12] “Functional expression of the human hZIP2 zinc transporter.”  Gaither L.A.et.al.   10681536
[13] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[14] “The DNA sequence and analysis of human chromosome 14.”  Heilig R.et.al.   12508121
[15] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEQLLGIKLG CLFALLALTL GCGLTPICFK WFQIDAARGH HRLVLRLLGC ISAGVFLGAG 
61:	FMHMTAEALE EIESQIQKFM VQNRSASERN SSGDADSAHM EYPYGELIIS LGFFFVFFLE 
121:	SLALQCCPGA AGGSTVQDEE WGGAHIFELH SHGHLPSPSK GPLRALVLLL SLSFHSVFEG 
181:	LAVGLQPTVA ATVQLCLAVL AHKGLVVFGV GMRLVHLGTS SRWAVFSILL LALMSPLGLA 
241:	VGLAVTGGDS EGGRGLAQAV LEGVAAGTFL YVTFLEILPR ELASPEAPLA KWSCVAAGFA 
301:	FMAFIALWA