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2.A.5.3.2
Zn2+ uptake transporter, Zip1 (abundantly expressed; involved in zinc homeostasis rather than acquisition of dietary Zn2+) (Gaither and Eide, 2000).  Mouse Zip1, 2 and 3 play important noncompensatory roles under conditions of zinc deficiency (Kambe et al. 2008).

Accession Number:Q9NY26
Protein Name:Zinc transporter ZIP1
Length:324
Molecular Weight:34250.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Zn2+

Cross database links:

NOG84653
Genevestigator: Q9NY26 Q9NY26
HEGENOM: HBG403167 HOG000236331
RefSeq: NP_055252.2   
Entrez Gene ID: 27173   
Pfam: PF02535   
OMIM: 604740  gene
KEGG: hsa:27173    hsa:27173   

Gene Ontology

GO:0005789 C:endoplasmic reticulum membrane
GO:0016021 C:integral to membrane
GO:0005624 C:membrane fraction
GO:0005886 C:plasma membrane
GO:0015674 P:di-, tri-valent inorganic cation transport
GO:0055085 P:transmembrane transport
GO:0006829 P:zinc ion transport
GO:0022890 F:inorganic cation transmembrane transporter activity
GO:0005385 F:zinc ion transmembrane transporter activity
GO:0071577 P:zinc ion transmembrane transport

References (14)

[1] “Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex.”  Lioumi M.et.al.   10610721
[2] “Differential subcellular localization of hZip1 in adherent and non-adherent cells.”  Milon B.et.al.   11696349
[3] “Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.”  Lai C.-H.et.al.   10810093
[4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells.”  Gaither L.A.et.al.   11301334
[7] “Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells.”  Franklin R.B.et.al.   12888280
[8] “Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex.”  Lioumi M.et.al.   10610721
[9] “Differential subcellular localization of hZip1 in adherent and non-adherent cells.”  Milon B.et.al.   11696349
[10] “Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.”  Lai C.-H.et.al.   10810093
[11] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[12] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[13] “The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells.”  Gaither L.A.et.al.   11301334
[14] “Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells.”  Franklin R.B.et.al.   12888280

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGPWGEPELL VWRPEAVASE PPVPVGLEVK LGALVLLLVL TLLCSLVPIC VLRRPGANHE 
61:	GSASRQKALS LVSCFAGGVF LATCLLDLLP DYLAAIDEAL AALHVTLQFP LQEFILAMGF 
121:	FLVLVMEQIT LAYKEQSGPS PLEETRALLG TVNGGPQHWH DGPGVPQASG APATPSALRA 
181:	CVLVFSLALH SVFEGLAVGL QRDRARAMEL CLALLLHKGI LAVSLSLRLL QSHLRAQVVA 
241:	GCGILFSCMT PLGIGLGAAL AESAGPLHQL AQSVLEGMAA GTFLYITFLE ILPQELASSE 
301:	QRILKVILLL AGFALLTGLL FIQI