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2.A.5.4.1
Zip4 Zn2+ uptake transporter (Acrodermatitis enteropathica zinc-deficiency disease protein) (Dufner-Beattie et al., 2003).  The large cytoplasmic loop is an intrinsically disordered zinc binding domain (Bafaro et al. 2015). A modeled ZIP4 dimer possibly resembles the twelve TMS monomeric PiPT of the MFS, as a likely structural homologue (Antala et al. 2015).

Accession Number:Q6P5W5
Protein Name:Zinc transporter ZIP4
Length:647
Molecular Weight:68392.00
Species: [9606]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Zn2+

Cross database links:

Genevestigator: Q6P5W5 Q6P5W5
eggNOG: prNOG11089 COG0428
HEGENOM: HBG714872 HOG000293181
RefSeq: NP_060237.2    NP_570901.2   
Entrez Gene ID: 55630   
Pfam: PF02535   
OMIM: 201100  phenotype
607059  gene
KEGG: hsa:55630    hsa:55630   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0055038 C:recycling endosome membrane
GO:0055085 P:transmembrane transport
GO:0006829 P:zinc ion transport
GO:0016324 C:apical plasma membrane
GO:0016023 C:cytoplasmic membrane-bounded vesicle
GO:0005886 C:plasma membrane
GO:0005385 F:zinc ion transmembrane transporter activity
GO:0034224 P:cellular response to zinc ion starvation
GO:0006882 P:cellular zinc ion homeostasis

References (14)

[1] “Identification of SLC39A4, a gene involved in acrodermatitis enteropathica.”  Kuery S.et.al.   12068297
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “DNA sequence and analysis of human chromosome 8.”  Nusbaum C.et.al.   16421571
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “A novel member of a zinc transporter family is defective in acrodermatitis enteropathica.”  Wang K.et.al.   12032886
[6] “Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane.”  Kim B.-E.et.al.   14612438
[7] “Novel SLC39A4 mutations in acrodermatitis enteropathica.”  Nakano A.et.al.   12787121
[8] “Identification of SLC39A4, a gene involved in acrodermatitis enteropathica.”  Kuery S.et.al.   12068297
[9] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[10] “DNA sequence and analysis of human chromosome 8.”  Nusbaum C.et.al.   16421571
[11] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[12] “A novel member of a zinc transporter family is defective in acrodermatitis enteropathica.”  Wang K.et.al.   12032886
[13] “Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane.”  Kim B.-E.et.al.   14612438
[14] “Novel SLC39A4 mutations in acrodermatitis enteropathica.”  Nakano A.et.al.   12787121

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MASLVSLELG LLLAVLVVTA TASPPAGLLS LLTSGQGALD QEALGGLLNT LADRVHCANG 
61:	PCGKCLSVED ALGLGEPEGS GLPPGPVLEA RYVARLSAAA VLYLSNPEGT CEDARAGLWA 
121:	SHADHLLALL ESPKALTPGL SWLLQRMQAR AAGQTPKTAC VDIPQLLEEA VGAGAPGSAG 
181:	GVLAALLDHV RSGSCFHALP SPQYFVDFVF QQHSSEVPMT LAELSALMQR LGVGREAHSD 
241:	HSHRHRGASS RDPVPLISSS NSSSVWDTVC LSARDVMAAY GLSEQAGVTP EAWAQLSPAL 
301:	LQQQLSGACT SQSRPPVQDQ LSQSERYLYG SLATLLICLC AVFGLLLLTC TGCRGVTHYI 
361:	LQTFLSLAVG ALTGDAVLHL TPKVLGLHTH SEEGLSPQPT WRLLAMLAGL YAFFLFENLF 
421:	NLLLPRDPED LEDGPCGHSS HSHGGHSHGV SLQLAPSELR QPKPPHEGSR ADLVAEESPE 
481:	LLNPEPRRLS PELRLLPYMI TLGDAVHNFA DGLAVGAAFA SSWKTGLATS LAVFCHELPH 
541:	ELGDFAALLH AGLSVRQALL LNLASALTAF AGLYVALAVG VSEESEAWIL AVATGLFLYV 
601:	ALCDMLPAML KVRDPRPWLL FLLHNVGLLG GWTVLLLLSL YEDDITF