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2.A.5.4.12
ZIP13 Zn influx porter, an 8TMS homodimer with N- and C-termini facing the lumen of the Golgi. Important for connective tissue development. Its loss causes the Spondylocheiro dysplastic form of Ehlers-Danlos syndrome (Bin et al., 2011).

Accession Number:Q96H72
Protein Name:Zinc transporter ZIP13
Length:371
Molecular Weight:39011.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Zn2+

Cross database links:

Genevestigator: Q96H72 Q96H72
eggNOG: prNOG16324 COG0428
HEGENOM: HBG715717 HOG000185308
Entrez Gene ID: 91252   
Pfam: PF02535   
KEGG: hsa:91252    hsa:91252   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0046873 F:metal ion transmembrane transporter activity
GO:0006829 P:zinc ion transport
GO:0030173 C:integral to Golgi membrane
GO:0048471 C:perinuclear region of cytoplasm
GO:0005385 F:zinc ion transmembrane transporter activity
GO:0006882 P:cellular zinc ion homeostasis
GO:0061448 P:connective tissue development

References (11)

[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[2] “Human chromosome 11 DNA sequence and analysis including novel gene identification.”  Taylor T.D.et.al.   16554811
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[5] “Spondylocheiro dysplastic form of the Ehlers-Danlos syndrome -- an autosomal-recessive entity caused by mutations in the zinc transporter gene SLC39A13.”  Giunta C.et.al.   18513683
[6] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[7] “Human chromosome 11 DNA sequence and analysis including novel gene identification.”  Taylor T.D.et.al.   16554811
[8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[9] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[10] “Biochemical characterization of human ZIP13 protein: a homo-dimerized zinc transporter involved in the spondylocheiro dysplastic Ehlers-Danlos syndrome.”  Bin B.H.et.al.   21917916
[11] “Spondylocheiro dysplastic form of the Ehlers-Danlos syndrome -- an autosomal-recessive entity caused by mutations in the zinc transporter gene SLC39A13.”  Giunta C.et.al.   18513683

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPGCPCPGCG MAGPRLLFLT ALALELLERA GGSQPALRSR GTATACRLDN KESESWGALL 
61:	SGERLDTWIC SLLGSLMVGL SGVFPLLVIP LEMGTMLRSE AGAWRLKQLL SFALGGLLGN 
121:	VFLHLLPEAW AYTCSASPGG EGQSLQQQQQ LGLWVIAGIL TFLALEKMFL DSKEEGTSQA 
181:	PNKDPTAAAA ALNGGHCLAQ PAAEPGLGAV VRSIKVSGYL NLLANTIDNF THGLAVAASF 
241:	LVSKKIGLLT TMAILLHEIP HEVGDFAILL RAGFDRWSAA KLQLSTALGG LLGAGFAICT 
301:	QSPKGVVGCS PAAEETAAWV LPFTSGGFLY IALVNVLPDL LEEEDPWRSL QQLLLLCAGI 
361:	VVMVLFSLFV D