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2.A.5.4.14
solute carrier family 39 (zinc transporter), member 12

Accession Number:Q504Y0
Protein Name:Zinc transporter ZIP12
Length:691
Molecular Weight:76666.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Zn2+

Cross database links:

Genevestigator: Q504Y0 Q504Y0
eggNOG: COG0428 COG0428
Entrez Gene ID: 221074   
Pfam: PF02535   
KEGG: hsa:221074    hsa:221074   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0046873 F:metal ion transmembrane transporter activity
GO:0006829 P:zinc ion transport

References (14)

[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[2] “The DNA sequence and comparative analysis of human chromosome 10.”  Deloukas P.et.al.   15164054
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Expressed sequence tag analysis of human RPE/choroid for the NEIBank project: over 6000 non-redundant transcripts, novel genes and splice variants.”  Wistow G.et.al.   12107410
[5] “Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.”  Suzuki Y.et.al.   15342556
[6] “Examination of the zinc transporter gene, SLC39A12.”  Bly M.et.al.   16311021
[7] “The consensus coding sequences of human breast and colorectal cancers.”  Sjoeblom T.et.al.   16959974
[8] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[9] “The DNA sequence and comparative analysis of human chromosome 10.”  Deloukas P.et.al.   15164054
[10] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[11] “Expressed sequence tag analysis of human RPE/choroid for the NEIBank project: over 6000 non-redundant transcripts, novel genes and splice variants.”  Wistow G.et.al.   12107410
[12] “Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.”  Suzuki Y.et.al.   15342556
[13] “Examination of the zinc transporter gene, SLC39A12.”  Bly M.et.al.   16311021
[14] “The consensus coding sequences of human breast and colorectal cancers.”  Sjoeblom T.et.al.   16959974

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MCFRTKLSVS WVPLFLLLSR VFSTETDKPS AQDSRSRGSS GQPADLLQVL SAGDHPPHNH 
61:	SRSLIKTLLE KTGCPRRRNG MQGDCNLCFE PDALLLIAGG NFEDQLREEV VQRVSLLLLY 
121:	YIIHQEEICS SKLNMSNKEY KFYLHSLLSL RQDEDSSFLS QNETEDILAF TRQYFDTSQS 
181:	QCMETKTLQK KSGIVSSEGA NESTLPQLAA MIITLSLQGV CLGQGNLPSP DYFTEYIFSS 
241:	LNRTNTLRLS ELDQLLNTLW TRSTCIKNEK IHQFQRKQNN IITHDQDYSN FSSSMEKESE 
301:	DGPVSWDQTC FSARQLVEIF LQKGLSLISK EDFKQMSPGI IQQLLSCSCH LPKDQQAKLP 
361:	PTTLEKYGYS TVAVTLLTLG SMLGTALVLF HSCEENYRLI LQLFVGLAVG TLSGDALLHL 
421:	IPQVLGLHKQ EAPEFGHFHE SKGHIWKLMG LIGGIHGFFL IEKCFILLVS PNDKQGLSLV 
481:	NGHVGHSHHL ALNSELSDQA GRGKSASTIQ LKSPEDSQAA EMPIGSMTAS NRKCKAISLL 
541:	AIMILVGDSL HNFADGLAIG AAFSSSSESG VTTTIAILCH EIPHEMGDFA VLLSSGLSMK 
601:	TAILMNFISS LTAFMGLYIG LSVSADPCVQ DWIFTVTAGM FLYLSLVEML PEMTHVQTQR 
661:	PWMMFLLQNF GLILGWLSLL LLAIYEQNIK I