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2.A.5.4.16
Zinc transporter Foi (Protein fear-of-intimacy) (Protein kastchen)

Accession Number:Q9VSL7
Protein Name:Zinc transporter foi
Length:706
Molecular Weight:77376.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Zn2+

Cross database links:

eggNOG: COG0428
Entrez Gene ID: 38976   
Pfam: PF02535   
KEGG: dme:Dmel_CG6817   

Gene Ontology

GO:0009986 C:cell surface
GO:0005887 C:integral to plasma membrane
GO:0005385 F:zinc ion transmembrane transporter activity
GO:0035147 P:branch fusion, open tracheal system
GO:0030154 P:cell differentiation
GO:0007417 P:central nervous system development
GO:0035262 P:gonad morphogenesis
GO:0007506 P:gonadal mesoderm development
GO:0007280 P:pole cell migration

References (6)

[1] “fear of intimacy encodes a novel transmembrane protein required for gonad morphogenesis in Drosophila.”  Van Doren M.et.al.   12702650
[2] “The Drosophila transmembrane protein Fear-of-intimacy controls glial cell migration.”  Pielage J.et.al.   15464587
[3] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[4] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[5] “Drosophila fear of intimacy encodes a Zrt/IRT-like protein (ZIP) family zinc transporter functionally related to mammalian ZIP proteins.”  Mathews W.R.et.al.   15509557
[6] “Phosphoproteome analysis of Drosophila melanogaster embryos.”  Zhai B.et.al.   18327897

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MARHIMAVCV VCLLCAHRLH CQDHIESLLG PARVTTHNSQ DQLNARVYTN LSPSSETTDR 
61:	RQQRSASGDD DTFNYSISPP SRREKRHAGH EHGPTSESRV PQITQYYLEK LMAQDELMNS 
121:	SGFDGLLQQL SLHSLASGAS EGTCVPGSRL VHHVQPHDHH HAHHHEEEDH SLQLNNCTLI 
181:	QNGTTSNVIC PSLPNNNTHP LGKEAKNFTL SDKDLLHLCP ILLYELKAQS GGCIEPAILS 
241:	DIDTTEELLE AEKDKDIFYV WIYAFISVFA CGILGLVGVA IIPFMGSRYY KYIIQYLVAL 
301:	AVGTMTGDAL LHLLPHSLAG QDERGMIMKG LGCLGGIIFF YVMEHALTMI SEWRKSVEKK 
361:	ETKKPSRAKV MRDPDSSVNN SVAGDKICKQ KYSSYPYCYD EITMNNKQSE WMHLPFDVAA 
421:	GAGGDAPSVA ELRNGVGDHD GSNDMAAAAE SLISPLHTNC VEMNHHNHNH KHNSHQQNHE 
481:	GQDSNTIVTD LDGNAVYAVN KAKDKDSRND HVTVILREHE SSHHGHSHRH GHVHSPPETL 
541:	SAVAWMIIMG DGLHNFTDGM AIGAAFAENI AGGFSTSLAV FCHELPHELG DFAILIKAGM 
601:	SVKSAVYYNL LTGVLSFIGM IFGIAFGQSQ DVAQWMFAVA AGLFIYIALV DMMPEISASH 
661:	KSLGQFLLQI LGMLSGVGIM LLIALYEGDL MSAFGTAGAA SHQHAH