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2.A.5.4.3
Zip7 Golgi Zn2+ uptake (into the cytoplasm) transporter (Ke4, Slc39a7) (Huang et al., 2005). This protein can substitute for Iar1, the indole acetic acid-alanine resistance protein, of A. thaliana (Lasswell et al., 2000)

Accession Number:Q92504
Protein Name:Ke4
Length:469
Molecular Weight:50118.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Zn2+

Cross database links:

COG0428
Genevestigator: Q92504 Q92504
HEGENOM: HBG715717 HOG000185308
RefSeq: NP_001070984.1    NP_008910.2   
Entrez Gene ID: 7922   
Pfam: PF02535   
OMIM: 601416  gene
KEGG: hsa:7922    hsa:7922   

Gene Ontology

GO:0005789 C:endoplasmic reticulum membrane
GO:0016021 C:integral to membrane
GO:0005624 C:membrane fraction
GO:0005515 F:protein binding
GO:0005385 F:zinc ion transmembrane transporter activity
GO:0055085 P:transmembrane transport
GO:0006829 P:zinc ion transport
GO:0046873 F:metal ion transmembrane transporter activity

References (16)

[1] “cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region.”  Ando A.et.al.   8812499
[2] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters.”  Taylor K.M.et.al.   12839489
[5] “Global phosphoproteome of HT-29 human colon adenocarcinoma cells.”  Kim J.-E.et.al.   16083285
[6] “Phosphoproteome of resting human platelets.”  Zahedi R.P.et.al.   18088087
[7] “Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.”  Daub H.et.al.   18691976
[8] “Large-scale proteomics analysis of the human kinome.”  Oppermann F.S.et.al.   19369195
[9] “cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region.”  Ando A.et.al.   8812499
[10] “The DNA sequence and analysis of human chromosome 6.”  Mungall A.J.et.al.   14574404
[11] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[12] “Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters.”  Taylor K.M.et.al.   12839489
[13] “Global phosphoproteome of HT-29 human colon adenocarcinoma cells.”  Kim J.-E.et.al.   16083285
[14] “Phosphoproteome of resting human platelets.”  Zahedi R.P.et.al.   18088087
[15] “Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.”  Daub H.et.al.   18691976
[16] “Large-scale proteomics analysis of the human kinome.”  Oppermann F.S.et.al.   19369195

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MARGLGAPHW VAVGLLTWAT LGLLVAGLGG HDDLHDDLQE DFHGHSHRHS HEDFHHGHSH 
61:	AHGHGHTHES IWHGHTHDHD HGHSHEDLHH GHSHGYSHES LYHRGHGHDH EHSHGGYGES 
121:	GAPGIKQDLD AVTLWAYALG ATVLISAAPF FVLFLIPVES NSPRHRSLLQ ILLSFASGGL 
181:	LGDAFLHLIP HALEPHSHHT LEQPGHGHSH SGQGPILSVG LWVLSGIVAF LVVEKFVRHV 
241:	KGGHGHSHGH GHAHSHTRGS HGHGRQERST KEKQSSEEEE KETRGVQKRR GGSTVPKDGP 
301:	VRPQNAEEEK RGLDLRVSGY LNLAADLAHN FTDGLAIGAS FRGGRGLGIL TTMTVLLHEV 
361:	PHEVGDFAIL VQSGCSKKQA MRLQLLTAVG ALAGTACALL TEGGAVGSEI AGGAGPGWVL 
421:	PFTAGGFIYV ATVSVLPELL REASPLQSLL EVLGLLGGVI MMVLIAHLE