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2.A.5.4.4
Bidirectional endoplasmic reticular Zn2+ transporter, Yke4 (346 aas; Kumanovics et al., 2006)

Accession Number:P40544
Protein Name:Yke4
Length:346
Molecular Weight:37418.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate Zn2+

Cross database links:

Genevestigator: P40544
eggNOG: fuNOG06703
HEGENOM: HBG715717
DIP: DIP-5638N
RefSeq: NP_012241.1   
Entrez Gene ID: 854789   
Pfam: PF02535   
KEGG: sce:YIL023C   

Gene Ontology

GO:0005789 C:endoplasmic reticulum membrane
GO:0016021 C:integral to membrane
GO:0005385 F:zinc ion transmembrane transporter activity
GO:0055085 P:transmembrane transport
GO:0006829 P:zinc ion transport

References (3)

[1] “The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.”  Churcher C.M.et.al.   9169870
[2] “YKE4 (YIL023C) encodes a bidirectional zinc transporter in the endoplasmic reticulum of Saccharomyces cerevisiae.”  Kumanovics A.et.al.   16760462
[3] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKASHICSYL LSIAPLVVSH GVHHNRDHGH EANHESKQSF LILKQESIFY SLVCFLQNHL 
61:	FVLGPRYNAI VAILIIQLMP CLFVLFVPGL RKNDRASLTL SLLVSFSLGT LLGDILLHVI 
121:	PESLSGVTDV TMVGGAIFLG FISFLTLDKT MRILSGTSND DGSIHSHSHS HTPQQTAEKK 
181:	AGFNMSAYLN VISGIAHHIT DGIALATSFY SSTQVGIMTS IAVTFHEIPH ELGDFAILLS 
241:	SGFTFPQAIR AQAVTAFGAV VGTSIGCWMN EIGNNSHKAT SSSANASELM LPFTAGGLIY 
301:	IATTSVVPQI LHSSAPDSKL REFKKWALQL VFIFVGFAVM ALMDEH