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2.A.5.4.5
Zip14 Zn2+/Fe2+/Mn2+/Cd2+ uptake transporter (mobilized to the sinusoidal membrane of the hepatocyte during acute inflammation) (Jenkitkasemwong et al. 2012; Pinilla-Tenas et al., 2011); KM for Fe2+= 0.002 μM.  The prion gene family may have descended from an ancestral LZT gene (Ehsani et al. 2012).  The gene is upregulated by iron loading (Nam et al. 2013). LIV-1 ZIP ectodomain shedding in prion-infected mice resembles the cellular response to transition metal starvation (Ehsani et al. 2012).  Zip14 promotes cellular assimilation of iron from transferrin (Zhao et al. 2010) and also plays a role in maintaining manganese homeostasis (Xin et al. 2017). SLC39A14 is essential for efficient Mn2+ uptake by the liver and pancreas, and its deficiency results in impaired Mn2+ excretion and accumulation of the metal in other tissues (Jenkitkasemwong et al. 2018). Mutations cause hypermanganesemia associated with infantile onset dystonia (Juneja et al. 2018). .

Accession Number:Q15043
Protein Name:Zinc transporter ZIP14
Length:492
Molecular Weight:54196.00
Species: [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Zn2+, Fe2+, Mn2+, Cd2+

Cross database links:

HOG000070225
Genevestigator: Q15043 Q15043
eggNOG: prNOG05004 COG0428
RefSeq: NP_001121903.1    NP_001128625.1    NP_001128626.1    NP_056174.2   
Entrez Gene ID: 23516   
Pfam: PF02535   
OMIM: 608736  gene
KEGG: hsa:23516    hsa:23516   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0030027 C:lamellipodium
GO:0005886 C:plasma membrane
GO:0055085 P:transmembrane transport
GO:0006829 P:zinc ion transport
GO:0005783 C:endoplasmic reticulum
GO:0005794 C:Golgi apparatus
GO:0005887 C:integral to plasma membrane
GO:0005385 F:zinc ion transmembrane transporter activity
GO:0006882 P:cellular zinc ion homeostasis
GO:0071578 P:zinc ion import

References (16)

[1] “Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.”  Nomura N.et.al.   7584044
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “DNA sequence and analysis of human chromosome 8.”  Nusbaum C.et.al.   16421571
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “The LZT proteins; the LIV-1 subfamily of zinc transporters.”  Taylor K.M.et.al.   12659941
[6] “Structure-function analysis of a novel member of the LIV-1 subfamily of zinc transporters, ZIP14.”  Taylor K.M.et.al.   15642354
[7] “Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.”  Chen R.et.al.   19159218
[8] “Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.”  Wollscheid B.et.al.   19349973
[9] “Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.”  Nomura N.et.al.   7584044
[10] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[11] “DNA sequence and analysis of human chromosome 8.”  Nusbaum C.et.al.   16421571
[12] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[13] “The LZT proteins; the LIV-1 subfamily of zinc transporters.”  Taylor K.M.et.al.   12659941
[14] “Structure-function analysis of a novel member of the LIV-1 subfamily of zinc transporters, ZIP14.”  Taylor K.M.et.al.   15642354
[15] “Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.”  Chen R.et.al.   19159218
[16] “Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.”  Wollscheid B.et.al.   19349973

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FASTA formatted sequence
1:	MKLLLLHPAF QSCLLLTLLG LWRTTPEAHA SSPGAPAISA ASFLQDLIHR YGEGDSLTLQ 
61:	QLKALLNHLD VGVGRGNVTQ HVQGHRNLST CFSSGDLFTA HNFSEQSRIG SSELQEFCPT 
121:	ILQQLDSRAC TSENQENEEN EQTEEGRPSA VEVWGYGLLC VTVISLCSLL GASVVPFMKK 
181:	TFYKRLLLYF IALAIGTLYS NALFQLIPEA FGFNPLEDYY VSKSAVVFGG FYLFFFTEKI 
241:	LKILLKQKNE HHHGHSHYAS ESLPSKKDQE EGVMEKLQNG DLDHMIPQHC SSELDGKAPM 
301:	VDEKVIVGSL SVQDLQASQS ACYWLKGVRY SDIGTLAWMI TLSDGLHNFI DGLAIGASFT 
361:	VSVFQGISTS VAILCEEFPH ELGDFVILLN AGMSIQQALF FNFLSACCCY LGLAFGILAG 
421:	SHFSANWIFA LAGGMFLYIS LADMFPEMNE VCQEDERKGS ILIPFIIQNL GLLTGFTIMV 
481:	VLTMYSGQIQ IG