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2.A.5.4.6
Zinc transporter, Zip10 (plays an essential role in the migratory activity of highly metastatic breast cancer cells) (Kagara et al., 2007).  May be an evolutionary precursor of prion proteins in mammals (Schmitt-Ulms et al. 2009).

Accession Number:Q9ULF5
Protein Name:Zip10
Length:831
Molecular Weight:94132.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Zn2+

Cross database links:

COG0428
Genevestigator: Q9ULF5 Q9ULF5
HEGENOM: HBG443965 HOG000013093
RefSeq: NP_001120729.1    NP_065075.1   
Entrez Gene ID: 57181   
Pfam: PF02535   
OMIM: 608733  gene
KEGG: hsa:57181    hsa:57181   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0046873 F:metal ion transmembrane transporter activity
GO:0055085 P:transmembrane transport
GO:0006829 P:zinc ion transport

References (14)

[1] “Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.”  Nagase T.et.al.   10574462
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.”  Olsen J.V.et.al.   17081983
[6] “Zinc and its transporter ZIP10 are involved in invasive behavior of breast cancer cells.”  Kagara N.et.al.   17359283
[7] “Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.”  Daub H.et.al.   18691976
[8] “Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.”  Nagase T.et.al.   10574462
[9] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[10] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[11] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[12] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.”  Olsen J.V.et.al.   17081983
[13] “Zinc and its transporter ZIP10 are involved in invasive behavior of breast cancer cells.”  Kagara N.et.al.   17359283
[14] “Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.”  Daub H.et.al.   18691976

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKVHMHTKFC LICLLTFIFH HCNHCHEEHD HGPEALHRQH RGMTELEPSK FSKQAAENEK 
61:	KYYIEKLFER YGENGRLSFF GLEKLLTNLG LGERKVVEIN HEDLGHDHVS HLDILAVQEG 
121:	KHFHSHNHQH SHNHLNSENQ TVTSVSTKRN HKCDPEKETV EVSVKSDDKH MHDHNHRLRH 
181:	HHRLHHHLDH NNTHHFHNDS ITPSERGEPS NEPSTETNKT QEQSDVKLPK GKRKKKGRKS 
241:	NENSEVITPG FPPNHDQGEQ YEHNRVHKPD RVHNPGHSHV HLPERNGHDP GRGHQDLDPD 
301:	NEGELRHTRK REAPHVKNNA IISLRKDLNE DDHHHECLNV TQLLKYYGHG ANSPISTDLF 
361:	TYLCPALLYQ IDSRLCIEHF DKLLVEDINK DKNLVPEDEA NIGASAWICG IISITVISLL 
421:	SLLGVILVPI INQGCFKFLL TFLVALAVGT MSGDALLHLL PHSQGGHDHS HQHAHGHGHS 
481:	HGHESNKFLE EYDAVLKGLV ALGGIYLLFI IEHCIRMFKH YKQQRGKQKW FMKQNTEEST 
541:	IGRKLSDHKL NNTPDSDWLQ LKPLAGTDDS VVSEDRLNET ELTDLEGQQE SPPKNYLCIE 
601:	EEKIIDHSHS DGLHTIHEHD LHAAAHNHHG ENKTVLRKHN HQWHHKHSHH SHGPCHSGSD 
661:	LKETGIANIA WMVIMGDGIH NFSDGLAIGA AFSAGLTGGI STSIAVFCHE LPHELGDFAV 
721:	LLKAGMTVKQ AIVYNLLSAM MAYIGMLIGT AVGQYANNIT LWIFAVTAGM FLYVALVDML 
781:	PEMLHGDGDN EEHGFCPVGQ FILQNLGLLF GFAIMLVIAL YEDKIVFDIQ F