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2.A.5.4.8
The divalent cation (M2+): bicarbonate (HCO3-) transporter (M2+:HCO3- = 1:2). Transports Cd2+ and Zn2+, and probably Cu2+, Pb2+, and Hg2+ (based on competitive inhibition studies (Liu et al., 2008))

Accession Number:Q91W10
Protein Name:Zip8
Length:462
Molecular Weight:50082.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Metal ions, bicarbonate, Cd2+, Zn2+, Cu2+, Pb2+, Hg2+

Cross database links:

Genevestigator: Q91W10
eggNOG: roNOG11011
HEGENOM: HBG443965
RefSeq: NP_001128621.1    NP_001128622.1    NP_080504.3   
Entrez Gene ID: 67547   
Pfam: PF02535   
KEGG: mmu:67547   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0046873 F:metal ion transmembrane transporter activity
GO:0055085 P:transmembrane transport
GO:0006829 P:zinc ion transport

References (2)

[1] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAPGRAVAGL LLLAATSLGH PSEGPELAFS EDVLSVFGAN RSLSAAQLGR LLERLGAASQ 
61:	QGALDLGQLH FNQCLSAEDI FSLHGFSNVT QITSSNFSAI CPAILQQLNF HPCEDLRKHN 
121:	AKPSLSEVWG YGFLSVTIIN LASLLGLILT PLIKKSYFPK ILTYFVGLAI GTLFSNAIFQ 
181:	LIPEAFGFNP KIDNYVEKAV AVFGGFYMLF FVERTLKMLL KTYGQNDHTH FRNDDFGSKE 
241:	KTHQPKTLPL PAVNGVTCYA NPAVTEPNGH IHFDTVSVVS LQDGKTEPSS CTCLKGPKLS 
301:	EIGTIAWMIT LCDALHNFID GLAIGASCTL SLLQGLSTSI AILCEEFPHE LGDFVILLNA 
361:	GMSTRQALLF NFLSACSCYV GLAFGILVGN NFAPNIIFAL AGGMFLYISL ADMFPEMNDM 
421:	LREKVTGRQT DFTFFMIQNA GMLTGFTAIL LITLYAGDIE LQ